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Cat. No.: HY-181941

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IDO1/TDO-IN-11

IDO1/TDO-IN-11 (Compound Y-13) is a dual IDO1 and TDO inhibitor, with an IC₅₀ of 2.87 μM against hIDO1 and an IC₅₀ of 0.08 μM against hTDO. IDO1/TDO-IN-11 inhibits NO production and ROS production. IDO1/TDO-IN-11 alleviates cellular neuroinflammatory damage and ameliorates Parkinson's disease. IDO1/TDO-IN-11 is applicable to research related to Parkinson's disease.

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화학식: C₁₈H₁₅NO₄
분자량:309.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1/TDO-IN-11 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

hIDO1

2.87 μM (IC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

All NO Synthase Isoforms :

In Vitro

IDO1/TDO-IN-11 potently inhibits purified hIDO1 (IC₅₀ = 2.87 ± 0.93 μM) and hTDO (IC₅₀ = 0.08 ± 0.01 μM) in cell-free biochemical assays^[1].
IDO1/TDO-IN-1 potently inhibits intracellular IDO1 activity in IFN-γ-induced HeLa cells, with an IC₅₀ of 10.97 ± 1.56 μM^[1].
IDO1/TDO-IN-11 potently inhibits intracellular TDO activity in hTDO-transfected HEK-293 T cells, with an IC₅₀ of 10.34 ± 0.55 μM^[1].
IDO1/TDO-IN-11 (5-80 μM) inhibits LPS-induced NO and ROS production in a concentration-dependent manner, thereby protecting BV2 microglia from neuroinflammatory injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IDO1/TDO-IN-11 (25-50 mg/kg; i.p.; once daily; 14 days) shows protective effects in MPTP (HY-W114750)-induced PD mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PD mouse model^[1]
Dosage:

25, 50 mg/kg
Administration:

i.p.; once daily; 14 days
Result:

Significantly prevented the
MPTP-induced deficits.
Had no obvious toxicity.
Reversed PD symptoms at the pathological level (H&E staining of mice brain section).
Improved cognitive function, learning ability, and motor
performance.

Chemical Information

분자량 309.32
화학식 C₁₈H₁₅NO₄
SMILES

OC1=C2C(C=C(C3=CC=C(C(OC)=O)C=C3)N=C2)=CC=C1OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang Z, et al. Design, synthesis and anti-Parkinson's disease bioactivity evaluation of isoquinoline derivatives as potent IDO1/TDO dual inhibitors. Bioorg Med Chem Lett. 2026 Feb 22;136:130596. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IDO1/TDO-IN-11

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

All NO Synthase Isoforms