IDO1/TDO-IN-11
IDO1/TDO-IN-11 (Compound Y-13) is a dual IDO1 and TDO inhibitor, with an IC50 of 2.87 μM against hIDO1 and an IC50 of 0.08 μM against hTDO. IDO1/TDO-IN-11 inhibits NO production and ROS production. IDO1/TDO-IN-11 alleviates cellular neuroinflammatory damage and ameliorates Parkinson's disease. IDO1/TDO-IN-11 is applicable to research related to Parkinson's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C18H15NO4
- Molecular Weight:309.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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hIDO1 2.87 μM (IC50) |
IDO1/TDO-IN-11 potently inhibits purified hIDO1 (IC50 = 2.87 ± 0.93 μM) and hTDO (IC50 = 0.08 ± 0.01 μM) in cell-free biochemical assays[1].
IDO1/TDO-IN-1 potently inhibits intracellular IDO1 activity in IFN-γ-induced HeLa cells, with an IC50 of 10.97 ± 1.56 μM[1].
IDO1/TDO-IN-11 potently inhibits intracellular TDO activity in hTDO-transfected HEK-293 T cells, with an IC50 of 10.34 ± 0.55 μM[1].
IDO1/TDO-IN-11 (5-80 μM) inhibits LPS-induced NO and ROS production in a concentration-dependent manner, thereby protecting BV2 microglia from neuroinflammatory injury[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:PD mouse model[1]
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Dosage:25, 50 mg/kg
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Administration:i.p.; once daily; 14 days
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Result:Significantly prevented the
MPTP-induced deficits.
Had no obvious toxicity.
Reversed PD symptoms at the pathological level (H&E staining of mice brain section).
Improved cognitive function, learning ability, and motor
performance.
Chemical Information
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Molecular Weight 309.32
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Formel C18H15NO4
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SMILES
OC1=C2C(C=C(C3=CC=C(C(OC)=O)C=C3)N=C2)=CC=C1OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IDO1/TDO-IN-11 Related Classifications
HY-181941 Related Classifications
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