2. Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Indoleamine 2,3-Dioxygenase (IDO) NO Synthase Reactive Oxygen Species (ROS)
  4. IDO1/TDO-IN-11

IDO1/TDO-IN-11 (Compound Y-13) is a dual IDO1 and TDO inhibitor, with an IC50 of 2.87 μM against hIDO1 and an IC50 of 0.08 μM against hTDO. IDO1/TDO-IN-11 inhibits NO production and ROS production. IDO1/TDO-IN-11 alleviates cellular neuroinflammatory damage and ameliorates Parkinson's disease. IDO1/TDO-IN-11 is applicable to research related to Parkinson's disease.

For research use only. We do not sell to patients.

IDO1/TDO-IN-11

IDO1/TDO-IN-11 Chemical Structure

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IDO1/TDO-IN-11 Related Antibodies

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nNOS iNOS eNOS

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Description

IDO1/TDO-IN-11 (Compound Y-13) is a dual IDO1 and TDO inhibitor, with an IC50 of 2.87 μM against hIDO1 and an IC50 of 0.08 μM against hTDO. IDO1/TDO-IN-11 inhibits NO production and ROS production. IDO1/TDO-IN-11 alleviates cellular neuroinflammatory damage and ameliorates Parkinson's disease. IDO1/TDO-IN-11 is applicable to research related to Parkinson's disease[1].

IC50 & Target[1]

hIDO1

2.87 μM (IC50)

In Vitro

IDO1/TDO-IN-11 potently inhibits purified hIDO1 (IC50 = 2.87 ± 0.93 μM) and hTDO (IC50 = 0.08 ± 0.01 μM) in cell-free biochemical assays[1].
IDO1/TDO-IN-1 potently inhibits intracellular IDO1 activity in IFN-γ-induced HeLa cells, with an IC50 of 10.97 ± 1.56 μM[1].
IDO1/TDO-IN-11 potently inhibits intracellular TDO activity in hTDO-transfected HEK-293 T cells, with an IC50 of 10.34 ± 0.55 μM[1].
IDO1/TDO-IN-11 (5-80 μM) inhibits LPS-induced NO and ROS production in a concentration-dependent manner, thereby protecting BV2 microglia from neuroinflammatory injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1/TDO-IN-11 Related Antibodies
In Vivo

IDO1/TDO-IN-11 (25-50 mg/kg; i.p.; once daily; 14 days) shows protective effects in MPTP (HY-W114750)-induced PD mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PD mouse model[1]
Dosage: 25, 50 mg/kg
Administration: i.p.; once daily; 14 days
Result: Significantly prevented the
MPTP-induced deficits.
Had no obvious toxicity.
Reversed PD symptoms at the pathological level (H&E staining of mice brain section).
Improved cognitive function, learning ability, and motor
performance.
Molecular Weight

309.32

Formula

C18H15NO4
SMILES

OC1=C2C(C=C(C3=CC=C(C(OC)=O)C=C3)N=C2)=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IDO1/TDO-IN-11 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1/TDO-IN-11Indoleamine 2,3-Dioxygenase (IDO)NO SynthaseReactive Oxygen Species (ROS)Nitric oxide synthasesNOSNO generationROS generationparkinson's diseaseHeLa cellshTDOBV2 microglial cellsHEK-293 T cellsneuroinflammationhIDO1tryptophan-kynurenine pathwayInhibitorinhibitorinhibit

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