2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO) Endogenous Metabolite
  4. (±)-Longamide

(±)-Longamide is a polycyclic bioactive metabolite isolated from sponges that has several bromopyrrole fragments, as well as a weak inhibitor of IDO1.

For research use only. We do not sell to patients.

(±)-Longamide

(±)-Longamide Chemical Structure

CAS No. : 219783-00-3

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(±)-Longamide Related Antibodies

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Description

(±)-Longamide is a polycyclic bioactive metabolite isolated from sponges that has several bromopyrrole fragments, as well as a weak inhibitor of IDO1[1].

Cellular Effect
Cell Line Type Value Description References
P388 ED50
> 100 μg/mL
Compound: 3
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 9834174]
Molecular Weight

309.94

Formula

C7H6Br2N2O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1NCC(N2C(Br)=C(C=C12)Br)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (177.45 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2264 mL 16.1322 mL 32.2643 mL
5 mM 0.6453 mL 3.2264 mL 6.4529 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2264 mL 16.1322 mL 32.2643 mL 80.6608 mL
5 mM 0.6453 mL 3.2264 mL 6.4529 mL 16.1322 mL
10 mM 0.3226 mL 1.6132 mL 3.2264 mL 8.0661 mL
15 mM 0.2151 mL 1.0755 mL 2.1510 mL 5.3774 mL
20 mM 0.1613 mL 0.8066 mL 1.6132 mL 4.0330 mL
25 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2264 mL
30 mM 0.1075 mL 0.5377 mL 1.0755 mL 2.6887 mL
40 mM 0.0807 mL 0.4033 mL 0.8066 mL 2.0165 mL
50 mM 0.0645 mL 0.3226 mL 0.6453 mL 1.6132 mL
60 mM 0.0538 mL 0.2689 mL 0.5377 mL 1.3443 mL
80 mM 0.0403 mL 0.2017 mL 0.4033 mL 1.0083 mL
100 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8066 mL
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(±)-Longamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Longamide219783-00-3Indoleamine 2,3-Dioxygenase (IDO)Endogenous MetabolitePolycyclic bioactive metabolitesspongesInhibitorinhibitorinhibit

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