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Cat. No.: HY-144274

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IDO1-IN-14

IDO1-IN-14 (compound 4a) is a potent IDO1 inhibitor with an IC₅₀ of 396.9 nM. IDO1-IN-14 has cellular IDO1 inhibition (HeLa EC₅₀=3393 nM).

For research use only. We do not sell to patients.

CAS No.: 3037206-49-5
Formula: C₁₈H₁₂Cl₂FN₃O₂
Molecular Weight:392.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IDO1-IN-14 Chemical Structure

CAS No.: 3037206-49-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IDO1-IN-14 (compound 4a) is a potent IDO1 inhibitor with an IC₅₀ of 396.9 nM. IDO1-IN-14 has cellular IDO1 inhibition (HeLa EC₅₀=3393 nM)^[1].

IC₅₀ & Target^[1]

IDO1

396.9 nM (EC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Chemical Information

CAS No. 3037206-49-5
Molecular Weight 392.21
Formula C₁₈H₁₂Cl₂FN₃O₂
SMILES

O/N=C(C1=CN=C(C=C1)OC2=CC(Cl)=CC=C2)/NC3=CC=C(C(Cl)=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yeh TK, et al. Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design. Eur J Med Chem. 2022;229:114043. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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