2. Metabolic Enzyme/Protease Apoptosis
  3. Indoleamine 2,3-Dioxygenase (IDO) Apoptosis
  4. ZC0109

ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC50s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis.

For research use only. We do not sell to patients.

ZC0109 Chemical Structure

ZC0109 Chemical Structure

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5 mg USD 540 In-stock
10 mg USD 860 In-stock
25 mg USD 1820 In-stock
50 mg USD 2900 In-stock
100 mg USD 4650 In-stock
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Based on 1 publication(s) in Google Scholar

ZC0109 Related Antibodies

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View All Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products:

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IDO1 IDO2 IDO

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  • Purity & Documentation

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Description

ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with IC50s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis[1].

IC50 & Target

IC50: 50 nM (IDO1), 3.0 μM (TrxR1)[1]
In Vitro

ZC0109 (24 h) inhibits cancer cells with IC50s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively[1].
ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells[1].
ZC0109 (2.5-10 μM; 24 h) induces apoptosis and G1/S cell cycle arrest in cancer cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZC0109 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells and HeLa cells
Concentration: 2.5 μM, 5 μM, and 10 μM
Incubation Time: 24 hours
Result: Arrested cell cycle at G1/S phase.
In Vivo

ZC0109 (15, 30, and 60 mg/kg; p.o.; once daily for 28 d) reduces Kyn/Trp metabolism in C57BL/6 mice[1].
ZC0109 (60 mg/kg; p.o.; once daily for 28 d) decreases tumor growth and increases accumulation and infiltration of T cells in CT-26 cells transplanted immunocompetent BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

591.41

Formula

C22H20BrFN8O4S
Appearance

Solid

Color

White to off-white

SMILES

O/N=C(C1=NON=C1NCCCC2=NN=C(S2)NC(CC3=CC=C(C=C3)O)=O)\NC4=CC(Br)=C(C=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6909 mL 8.4544 mL 16.9087 mL
5 mM 0.3382 mL 1.6909 mL 3.3817 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6909 mL 8.4544 mL 16.9087 mL 42.2719 mL
5 mM 0.3382 mL 1.6909 mL 3.3817 mL 8.4544 mL
10 mM 0.1691 mL 0.8454 mL 1.6909 mL 4.2272 mL
15 mM 0.1127 mL 0.5636 mL 1.1272 mL 2.8181 mL
20 mM 0.0845 mL 0.4227 mL 0.8454 mL 2.1136 mL
25 mM 0.0676 mL 0.3382 mL 0.6763 mL 1.6909 mL
30 mM 0.0564 mL 0.2818 mL 0.5636 mL 1.4091 mL
40 mM 0.0423 mL 0.2114 mL 0.4227 mL 1.0568 mL
50 mM 0.0338 mL 0.1691 mL 0.3382 mL 0.8454 mL
60 mM 0.0282 mL 0.1409 mL 0.2818 mL 0.7045 mL
80 mM 0.0211 mL 0.1057 mL 0.2114 mL 0.5284 mL
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ZC0109 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZC0109ZC 0109ZC-0109Indoleamine 2,3-Dioxygenase (IDO)ApoptosisInhibitorinhibitorinhibit

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