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IDO1-IN-21

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC₅₀ = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice.

For research use only. We do not sell to patients.

CAS No.: 2892432-98-1
Formula: C₂₁H₁₉F₂N₃O₆S
Molecular Weight:479.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IDO1-IN-21 Chemical Structure

CAS No.: 2892432-98-1

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC₅₀ = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice^[1].

IC₅₀ & Target^[1]

IDO1

0.64 μM (IC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

In Vitro

IDO1-IN-21 (0-50 μM; 48 h) inhibits the viability of SW480 cells with an IC₅₀ value of 28.64 μM^[1].
IDO1-IN-21 (0-10 μM; 48 h) inhibits the IDO1 of HeLa cells with an IC₅₀ value of 1.04 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SW480 cells
Concentration:

0-50 μM
Incubation Time:

48 h
Result:

Surpressed viability of SW480 cells (IC₅₀ = 28.64 μM).

In Vivo

IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) inhibits growth of tumor in CT26 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CT26 tumor-bearing mice^[1].
Dosage:

50, 100 mg/kg
Administration:

Intraperitoneal administration; every three day for 21 consecutive days.
Result:

Led to significant suppression of tumor growth.

Chemical Information

CAS No. 2892432-98-1
Molecular Weight 479.45
Formula C₂₁H₁₉F₂N₃O₆S
SMILES

O/N=C1C2=CC=C(OC)C=C2OC(C(N3CCN(CC3)S(=O)(C4=CC(F)=C(C=C4)F)=O)=O)=C\1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang K, et al. Discovery of novel sulfonamide chromone-oxime derivatives as potent indoleamine 2,3-dioxygenase 1 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115349. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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