2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. IDO1-IN-21

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice.

For research use only. We do not sell to patients.

IDO1-IN-21 Chemical Structure

IDO1-IN-21 Chemical Structure

CAS No. : 2892432-98-1

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IDO1-IN-21 Related Antibodies

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Description

IDO1-IN-21 (compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice[1].

IC50 & Target[1]

IDO1

0.64 μM (IC50)

In Vitro

IDO1-IN-21 (0-50 μM; 48 h) inhibits the viability of SW480 cells with an IC50 value of 28.64 μM[1].
IDO1-IN-21 (0-10 μM; 48 h) inhibits the IDO1 of HeLa cells with an IC50 value of 1.04 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-21 Related Antibodies

Cell Viability Assay[1]

Cell Line: SW480 cells
Concentration: 0-50 μM
Incubation Time: 48 h
Result: Surpressed viability of SW480 cells (IC50 = 28.64 μM).
In Vivo

IDO1-IN-21 (50, 100 mg/kg; i.p.; every three day for 21 consecutive days) inhibits growth of tumor in CT26 tumor-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 tumor-bearing mice[1].
Dosage: 50, 100 mg/kg
Administration: Intraperitoneal administration; every three day for 21 consecutive days.
Result: Led to significant suppression of tumor growth.
Molecular Weight

479.45

Formula

C21H19F2N3O6S
CAS No.
SMILES

O/N=C1C2=CC=C(OC)C=C2OC(C(N3CCN(CC3)S(=O)(C4=CC(F)=C(C=C4)F)=O)=O)=C\1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IDO1-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-212892432-98-1Indoleamine 2,3-Dioxygenase (IDO)tumorcancerSW480 cellsHeLa cellsInhibitorinhibitorinhibit

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