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Trypanosoma cruzi

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Autophagy (1) Bacterial (2) Casein Kinase (1) CDK (1) Cytochrome P450 (3) DNA/RNA Synthesis (2) Farnesyl Transferase (2) Fungal (4) GSK-3 (1) HBV (1) HIV (1) HSV (1) IFNAR (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (3) mRNA (1) Necroptosis (2) NTPDase (1) Parasite (71) Proteasome (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Ser/Thr Protease (1) Syk (1) TNF Receptor (1) Topoisomerase (2) Wnt (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (78) Inflammation/Immunology (3) Metabolic Disease (1)

By Targets:

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (3)

Autophagy (1)

Bacterial (2)

Casein Kinase (1)

CDK (1)

Cytochrome P450 (3)

DNA/RNA Synthesis (2)

Farnesyl Transferase (2)

Fungal (4)

GSK-3 (1)

HBV (1)

HIV (1)

HSV (1)

IFNAR (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (3)

mRNA (1)

Necroptosis (2)

NTPDase (1)

Parasite (71)

Proteasome (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

Ser/Thr Protease (1)

Syk (1)

TNF Receptor (1)

Topoisomerase (2)

Wnt (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (1)

Infection (78)

Inflammation/Immunology (3)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W040073

Nifurtimox 1 Publications Verification	Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-145669

DIF-3 5+ Cited Publications	Wnt CDK GSK-3	Infection Cancer
DIF-3 is an orally active anticancer agent. DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in cells. DIF-3 induces reactive oxygen species (ROS) and autophagy. DIF suppresses the growth of Trypanosoma. cruzi in HT1080 cells. DIF-3 exerts antitumor effects both in vitro and in vivo .

HY-W010538

trans-4-Methylcyclohexanamine	Parasite	Infection
trans-4-Methylcyclohexanamine is an intermediate and can be used for the development of T. cruzi enzyme inhibitor .

HY-21496

4-(Bromomethyl)benzoic acid 4-Carboxybenzyl bromide	Parasite	Infection
4-(Bromomethyl)benzoic acid (4-Carboxybenzyl bromide) is an antiparasitic agent with low activity against Leishmania amazonensis and Trypanosoma cruzi. 4-(Bromomethyl)benzoic acid has certain cytotoxicity to PBMCs, with an IC₅₀ of 88.8 μM .

HY-153238

AN15368	Parasite mRNA	Infection
AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-175741

IID432	Parasite Topoisomerase	Infection
IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC₅₀ of 8  nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research .

HY-108938

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .

HY-N12788

T-Cadinol	Parasite	Infection
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

HY-103033

T.cruzi-IN-1	Parasite	Infection
T.cruzi-IN-1 is a potent **Trypanosoma cruzi inhibitor with an IC₅₀** of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .

HY-N11173A

trans-Melilotoside	Parasite	Infection
trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria ^[1] ^[3].

HY-N2656

5,7,8-Trimethoxycoumarin	Parasite	Infection
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-168342

*Anti-Trypanosoma* cruzi agent-6**	Parasite	Infection
Anti-Trypanosoma cruzi agent-6 (Compound 8) exhibits inhibitory activity against Trypanosoma cruzi, that inhibits the epimastigote, trypomastigote and amastigote form of T. cruzi with IC₅₀s of 24.7 µM, 1.8 µM and 1.6 µM, respectively .

HY-151485

Anti-infective agent 5	Parasite	Infection
Anti-infective agent 5 (compound 74) is an orally active inhibitor of **Trypanosoma cruzi with an IC₅₀** value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .

HY-147765

*Anti-Trypanosoma* cruzi agent-3**	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-115972

*Anti-Trypanosoma* cruzi agent-2**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC₅₀ = 0.51 µM) and INC-5 epimastigote form (IC₅₀ = 3.06 µM), posseses anti-T. gondii activity .

HY-148323

*Anti-Trypanosoma* cruzi agent-4**	Parasite	Infection
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of **Trypanosoma cruzi*. Anti-Trypanosoma* cruzi agent-4 can be used for the research of infection .

HY-173461

*Anti-Trypanosoma* cruzi agent-7**	Parasite	Infection
Anti-Trypanosoma cruzi agent-7 (compound 1) is a potent **Trypanosoma cruzi inhibitor with an EC₅₀** of 1.26 µM. Anti-Trypanosoma cruzi agent-7 can be used in the study of Chagas disease .

HY-116004

*Anti-Trypanosoma* cruzi agent-5**	Parasite	Infection
Anti-Trypanosoma cruzi agent-5 (compoung 8) is a potent inhibitor of Trypanosoma cruzi proliferation .

HY-181516

*Anti-Trypanosoma* cruzi agent-8**	Parasite	Infection
Anti-Trypanosoma cruzi agent-8 is an anti-*Trypanosoma* agent and also a Trypanosoma cruzi trypanothione reductase (TcTR) inhibitor, with an IC₅₀ of 3.9 μM against TcTR. Anti-Trypanosoma cruzi agent-8 functionally inhibits the enzymatic activity of TcTR. Anti-Trypanosoma cruzi agent-8 exhibits trypanocidal activity against intracellular Trypanosoma cruzi amastigotes .

HY-115971

*Anti-Trypanosoma* cruzi agent-1**	Parasite	Infection Inflammation/Immunology
Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity .

HY-N3702

Dehydroabietinol	Syk	Infection Inflammation/Immunology
Dehydroabietinol is a SYK inhibitor with an IC₅₀ of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria .

HY-130752

VNI	Cytochrome P450 Parasite	Infection
VNI is an effective inhibitor of CYP51. VNI can inhibit sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity .

HY-185309

*Anti-Trypanosoma* cruzi agent-9**	Topoisomerase Parasite	Infection
Anti-Trypanosoma cruzi agent-9 is a topoisomerase II inhibitor. Anti-Trypanosoma cruzi agent-9 inhibits the growth of Trypanosoma cruzi and Leishmania donovani .

HY-107034

Moxipraquine 349C59	Parasite	Infection
Moxipraquine is a potent insecticide against Trypanosoma cruzi. Moxipraquine effectively inhibits Leishmania major, L. mexicana mexicana and L. brasiliensis panamensis but not L.b. brasiliensis .

HY-N10443

Mammea A/BA	Parasite Apoptosis Autophagy Reactive Oxygen Species (ROS)	Infection
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-118338

WRR-483	Parasite	Infection
WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.

HY-W040073R

Nifurtimox (Standard)	Reference Standards Parasite Lactate Dehydrogenase	Infection Cancer
Nifurtimox (Standard) is the analytical standard of Nifurtimox. This product is intended for research and analytical applications. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-151943

Antitrypanosomal agent 11	Parasite	Infection
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits **Trypanosoma cruzi with an IC₅₀** of 0.23 μM .

HY-151942

Antitrypanosomal agent 10	Parasite	Infection
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits **Trypanosoma cruzi with an IC₅₀** of 0.28 μM .

HY-172207

POPTc80-IN-1	Ser/Thr Protease Parasite	Infection
POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC₅₀ of 0.23 μM and a K_i of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC₅₀ of 46.71 μM .

HY-161299

LAPTc-IN-1	Parasite	Infection
LAPTc-IN-1 (compound 4) is a competitive inhibitor targeting acidic M17 leucinopeptidase (LAPTc) with K_i=0.27 μM. LAPTc-IN-1 is a potential antagonist of the parasite Trypanosoma cruzi .

HY-159097

T.cruzi-IN-4	Parasite	Infection
T.cruzi-IN-4 (Compound 21) is an anti-parasitic agent. T.cruzi-IN-4 inhibits the trypomastigote and amastigote form of Trypanosoma cruzi with IC₅₀ of 0.033 μM (120 h), T.cruzi-IN-4 inhibits the promastigote and amastigote form of Leishmania infantum with IC₅₀ of 28.74 and 61.82 μM. T.cruzi-IN-4 inhibits Leishmania amazonensis promastigote form with IC₅₀ of 18.38 μM .

HY-129228

Lychnopholide	Parasite	Infection
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .

HY-124623

DNDI-8219	Parasite	Infection
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Parasite	Infection
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-124112

PAM 1392	Parasite	Infection
PAM 1392 is active orally against *Plasmodium berghei* in mice, *P. cynofologi* and *P. knowlesi* in monkeys and **Trypanosoma cruzi in tissue cultures of mice, and hemolytic streptococci** in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria .

HY-N2970

Burchellin	Parasite	Infection
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-113907

SDZ-285604 VNF	Cytochrome P450 Parasite	Infection
SDZ-285604 (VNF) is a T. cruzi CYP51 inhibitor and can be used for study of Trypanosoma cruzi infection .

HY-121187

BiPNQ	Parasite	Infection
BiPNQ is a potent inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease .

HY-157028

Antiparasitic agent-19	Others	Infection
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .

HY-128663

GLK7-001	Parasite	Infection
GLK7-001 is a Trypanosoma cruzi glucokinase (TcGlcK) inhibitor. GLK7-001 has in vitro trypanocidal activity .

HY-155207

Antileishmanial agent-23	Parasite	Infection
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .

HY-146049

Antitrypanosomal agent 4	Parasite	Infection
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC₅₀s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-175304

DMU371	Parasite	Infection
DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC₅₀=185 nM). DMU371 is promising for research of infectious diseases .

HY-155103

Antitrypanosomal agent 15	Proteasome Parasite	Infection
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against Trypanosoma cruzi proteasome, with an _pIC₅₀ of 7.4 and <4 for T. cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Parasite	Infection
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-117129

MK 436 MK-0436	Parasite	Infection
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America .

HY-175305

DMU759	Parasite	Infection
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .

Cat. No.	Product Name	Target	Research Area

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12788

T-Cadinol	Citrus × aurantium Natsudaidai Terpenoids Sesquiterpenes Plants Salicaceae Source Classification	Parasite
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

HY-N11173A

trans-Melilotoside	Structural Classification Leguminosae Dendranthema morifolium (Ramat.) Tzvel. Coumarins Phenylpropanoids Plants Source Classification	Parasite
trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria ^[1] ^[3].

HY-N2656

5,7,8-Trimethoxycoumarin	Zanthoxylum dimorphophyllum Hemsl. Rutaceae Coumarins Phenylpropanoids Plants	Parasite
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .

HY-N3702

Dehydroabietinol	Structural Classification Terpenoids Verbenaceae Callicarpa bodinieri Levl. Diterpenoids Plants Source Classification	Syk
Dehydroabietinol is a SYK inhibitor with an IC₅₀ of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria .

HY-N10443

Mammea A/BA	other families Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb. Source Classification	Parasite Apoptosis Autophagy Reactive Oxygen Species (ROS)
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-129228

Lychnopholide	Lychnophora pseudovillosissima Semir & Leitão Terpenoids Sesquiterpenes Plants Compositae Source Classification	Parasite
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N10441

3β-Hydroxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Euphorbiaceae Plants Source Classification	Parasite
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .

HY-N2970

Burchellin	Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi Source Classification	Parasite
Burchellin is a neolignan that can inhibit Trypanosoma cruzi .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Alkaloids Simaroubaceae Other Alkaloids Eurycoma harmandiana Pierre Plants Source Classification	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-N1716

2′′-Acetylastragalin	Flavonoids Flavones Ranunculaceae Plants Delphinium staphisagria L. Source Classification	Parasite
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC₅₀ value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .

HY-N19727

Chamissonolide	Arnica chamissonis Less. Structural Classification Terpenoids Sesquiterpenes Plants Compositae Source Classification	Interleukin Related IFNAR TNF Receptor Apoptosis
Chamissonolide is a sesquiterpene lactone with cytotoxic, anti-inflammatory and trypanocidal activities. Chamissonolide reduces the mRNA levels of IL-2, IFN-γ, GM-CSF, iNOS and TNF-α, and upregulates the mRNA level of NF-ATc. Chamissonolide decreases the population of naturally occurring apoptotic cells. Chamissonolide can be used in research related to tumors, African trypanosomiasis and Chagas disease .

Cat. No.	Product Name	Chemical Structure

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

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