Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes.
For research use only. We do not sell to patients.
- Formula: C37H37N5O7
- Molecular Weight:663.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | CC50 |
>64 μM
Compound: 3
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Cytotoxicity against human MRC5 cells
Cytotoxicity against human MRC5 cells
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[PMID: 39378318] |
| Peritoneal macrophage | CC50 |
>64 μM
Compound: 3
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Cytotoxicity against mouse Peritoneal macrophage
Cytotoxicity against mouse Peritoneal macrophage
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[PMID: 39378318] |
Antimalarial agent 44 inhibits Leishmania infantum, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (EC50: 1.8, 3, 15, 9.1, 20 μM, respectively) [1].
Antimalarial agent 44 (pH 7.4) has a good cell permeability across MDCK-MDR1 cell monolayers, with Papp AB of 3.5 μcm/s[1].
Antimalarial agent 44 (pH 7.4) was efficiently cleared in mouse liver microsomes, with CLint of >580 μL/min/mg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 663.72
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Formula C37H37N5O7
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SMILES
O=C(C1=CC(NC(C2=NC=CC=C2)=O)=C(C=C1)OC3=CC=C(C[C@@H]4NC(OC(C)(C)C)=O)C=C3)CNC([C@H](CC5=CC=CC=C5)NC4=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 44 Related Classifications
HY-169194 Related Classifications
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