E5700 

E5700 is an orally active squalene synthase inhibitor, antimalarial agent and antifungal agent with an IC₅₀ of 0.49 nM (without PPi) against squalene synthase from T. cruzi epimastigotes. E5700 shows antiparasitic activities against Trypanosoma cruzi. E5700 inhibits the growth and alters the lipid prolife and the ultrastructure of a multiple agent-resistant C. tropicalis strain. E5700 is a potent and selective inhibitor of the growth of Leishmania amazonensis^[1][2][3].

433.54

C₂₆H₃₁N₃O₃

332132-39-5

O[C@@]1(CN2CCC1CC2)C#CC3=CC=C(N=C3CC4=CC=CC=C4)N5C[C@H]([C@H](C5)OC)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Urbina JA, et al. In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. Antimicrob Agents Chemother. 2004 Jul;48(7):2379-87.  [Content Brief]

  [2]. Ishida K, et al. Two squalene synthase inhibitors, E5700 and ER-119884, interfere with cellular proliferation and induce ultrastructural and lipid profile alterations in a Candida tropicalis strain resistant to fluconazole, itraconazole, and amphotericin B. J Infect Chemother. 2011 Aug;17(4):563-70.  [Content Brief]

  [3]. Fernandes Rodrigues JC, et al. In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects. Antimicrob Agents Chemother. 2008 Nov;52(11):4098-114.  [Content Brief]