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Cat. No.: HY-172206

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TSO-13

TSO-13 is the inhibitor for the main cysteine protease of Trypanosoma cruzi Cruzipain with an IC₅₀ of 2.2 μM. TSO-13 inhibits T. cruzi in Vero cell with an IC₅₀ of 1.9 μM.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₆N₄O₄S₂
Molecular Weight:604.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TSO-13 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TSO-13 is the inhibitor for the main cysteine protease of Trypanosoma cruzi Cruzipain with an IC₅₀ of 2.2 μM. TSO-13 inhibits T. cruzi in Vero cell with an IC₅₀ of 1.9 μM^[1].

All Parasite Isoforms :

Chemical Information

Molecular Weight 604.78
Formula C₃₂H₃₆N₄O₄S₂
SMILES

O=S(SC[C@H](N1C=C(N=N1)C(C2CCCCC2)NCC3=CC4=C(OCO4)C=C3)CC5=CC=CC=C5)(C6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cerutti J P, et al. Thiosulfonate-Based Targeted Covalent Cruzipain Inhibitors with Enhanced Bioactivity Translation for Antichagasic Therapy[J]. ACS Medicinal Chemistry Letters, 2025.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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TSO-13

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TSO-13 Related Classifications

HY-172206 Related Classifications