Anti-infective agent 4
Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection.
For research use only. We do not sell to patients.
- CAS No.: 2738381-52-5
- Formula: C19H12F3N5O4
- Molecular Weight:431.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>74 μM
Compound: 34j
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs
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[PMID: 33151678] |
| NIH3T3 | CC50 |
>37 μM
Compound: 73
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Cytotoxicity against mouse 3T3 cells
Cytotoxicity against mouse 3T3 cells
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[PMID: 36111399] |
Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.016 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3 cells
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Concentration:0.1 nM-100 μM
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Incubation Time:48 hours
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Result:Showed activity against 3T3 cells with an CC50 value of ＞37 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1]
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Dosage:50 mg/kg
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Administration:Oral gavage; 50 mg/kg once daily for five days
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Result:Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
Chemical Information
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CAS No. 2738381-52-5
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Molecular Weight 431.32
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Formula C19H12F3N5O4
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SMILES
O=C1C2=NC([N+]([O-])=O)=CN2C=CN1CC3=CC=C(C=N3)C4=CC=C(C=C4)OC(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-infective agent 4 Related Classifications
HY-151484 Related Classifications
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