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Cat. No.: HY-151484

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Anti-infective agent 4

Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC₅₀ value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2738381-52-5
Formule: C₁₉H₁₂F₃N₅O₄
Masse moléculaire:431.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Anti-infective agent 4 Chemical Structure

CAS No.: 2738381-52-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Trypanosoma

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	>74 μM Compound: 34j	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 20 hrs	[PMID: 33151678]
NIH3T3	CC₅₀	>37 μM Compound: 73	Cytotoxicity against mouse 3T3 cells Cytotoxicity against mouse 3T3 cells	[PMID: 36111399]

In Vitro

Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC₅₀ value of 0.016 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

3T3 cells
Concentration:

0.1 nM-100 μM
Incubation Time:

48 hours
Result:

Showed activity against 3T3 cells with an CC₅₀ value of ＞37 μM.

In Vivo

Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection^[1]
Dosage:

50 mg/kg
Administration:

Oral gavage; 50 mg/kg once daily for five days
Result:

Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.

Chemical Information

CAS No. 2738381-52-5
Masse moléculaire 431.32
Formule C₁₉H₁₂F₃N₅O₄
SMILES

O=C1C2=NC([N+]([O-])=O)=CN2C=CN1CC3=CC=C(C=N3)C4=CC=C(C=C4)OC(F)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ang CW, et al. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. J Med Chem. 2022 Sep 16. [Content Brief]

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Anti-infective agent 4

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Anti-infective agent 4 Related Classifications

HY-151484 Related Classifications