2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage Apoptosis
  3. Parasite Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis
  4. SET-12

SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS.

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SET-12

SET-12 Chemical Structure

CAS No. : 2241572-39-2

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SET-12 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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Description

SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS[1].

Molecular Weight

359.46

Formula

C21H29NO4
CAS No.
SMILES

O=C1OC[C@H](C(C)C)N1C([C@H]([C@H](O)CCC2=CC=CC=C2)/C=C/CC)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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SET-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SET-122241572-39-2SET12SET 12ParasiteReactive Oxygen Species (ROS)DNA/RNA SynthesisApoptosisLeishmania amazonensisTrypanosoma cruziChemotherapyNeglected diseaseN-acyl oxazolidin-2-onesInhibitorinhibitorinhibit

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