2241572-39-2
Chemical Structure
SET-12
- CAS No.: 2241572-39-2
- Formula:C21H29NO4
- Molecular Weight:359.46
InChIKey: MLMWAYLNPSKXLA-QFWABBIRSA-N
SMILES: O=C1OC[C@H](C(C)C)N1C([C@H]([C@H](O)CCC2=CC=CC=C2)/C=C/CC)=O
Biological Activity: SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS[1].
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SET-12 | SET-12 is an antiparasitic agent with high activity and selectivity against the Leishmania amazonensis. SET-12 exhibits excellent activity against the pre-flagellated form of the Leishmania amazonensis, with an IC₅₀ of 10.89 μM and a selectivity index (SI) of up to 12.1. SET-12 is also effective against the non-flagellated form within cells, with an IC₅₀ of 3.81 μM and a further increased selectivity index (SI) to 34.5. SET-12 causes signs of parasite cell apoptosis, including mitochondrial damage and accumulation of ROS. | |||||||||||||||||||||
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Keywords
