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Cat. No.: HY-181516

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Anti-Trypanosoma cruzi agent-8

Anti-Trypanosoma cruzi agent-8 is an anti-Trypanosoma agent and also a Trypanosoma cruzi trypanothione reductase (TcTR) inhibitor, with an IC₅₀ of 3.9 μM against TcTR. Anti-Trypanosoma cruzi agent-8 functionally inhibits the enzymatic activity of TcTR. Anti-Trypanosoma cruzi agent-8 exhibits trypanocidal activity against intracellular Trypanosoma cruzi amastigotes.

For research use only. We do not sell to patients.

Formula: C₂₄H₃₂N₂O₂
Molecular Weight:380.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Anti-Trypanosoma cruzi agent-8 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Trypanosoma

All Parasite Isoforms :

In Vitro

Anti-Trypanosoma cruzi agent-8 potently inhibits intracellular Trypanosoma cruzi amastigote with an IC₅₀ of 2.4 ± 0.3 μM^[1].
Anti-Trypanosoma cruzi agent-8 significantly inhibits recombinant Trypanosoma cruzi trypanothione reductase with an IC₅₀ of 3.9μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 380.52
Formula C₂₄H₃₂N₂O₂
SMILES

COC1=CC=CC=C1/C=C/CNCCCCNC/C=C/C2=CC=CC=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guarnieri OH, et al. Inhibitory effects against Trypanosoma cruzi, Leishmania infantum and trypanothione reductase of N¹,N⁴-bisbenzylbutane-1,4-diamines. Bioorg Med Chem Lett. 2026;134:130541. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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