2. Anti-infection Cell Cycle/DNA Damage
  3. Parasite Topoisomerase
  4. IID432

IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC50 of 8  nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research.

For research use only. We do not sell to patients.

IID432

IID432 Chemical Structure

CAS No. : 3094992-69-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

IID432 Related Antibodies

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Topoisomerase Topo I Topo II DNA gyrase

  • Biological Activity

  • Purity & Documentation

  • References

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Description

IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC50 of 8  nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research[1].

IC50 & Target[1]

Topoisomerase II

 

Molecular Weight

361.40

Formula

C19H19N7O
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

CC1=NC2=C(C=C(C=C2)N3CC[C@@H](C3)NC(CN4C=NC(C#N)=N4)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (138.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7670 mL 13.8351 mL 27.6702 mL
5 mM 0.5534 mL 2.7670 mL 5.5340 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7670 mL 13.8351 mL 27.6702 mL 69.1754 mL
5 mM 0.5534 mL 2.7670 mL 5.5340 mL 13.8351 mL
10 mM 0.2767 mL 1.3835 mL 2.7670 mL 6.9175 mL
15 mM 0.1845 mL 0.9223 mL 1.8447 mL 4.6117 mL
20 mM 0.1384 mL 0.6918 mL 1.3835 mL 3.4588 mL
25 mM 0.1107 mL 0.5534 mL 1.1068 mL 2.7670 mL
30 mM 0.0922 mL 0.4612 mL 0.9223 mL 2.3058 mL
40 mM 0.0692 mL 0.3459 mL 0.6918 mL 1.7294 mL
50 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3835 mL
60 mM 0.0461 mL 0.2306 mL 0.4612 mL 1.1529 mL
80 mM 0.0346 mL 0.1729 mL 0.3459 mL 0.8647 mL
100 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.6918 mL
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IID432 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IID4323094992-69-2IID 432IID-432ParasiteTopoisomeraseInhibitorTopoisomerase IITrypanosoma cruziChagas diseaseinhibitorinhibit

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