3094992-69-2
Chemical Structure
IID432
- CAS No.: 3094992-69-2
- Formula:C19H19N7O
- Molecular Weight:361.40
IUPAC Name: (S)-2-(3-cyano-1H-1,2,4-triazol-1-yl)-N-(1-(2-methylquinolin-6-yl)pyrrolidin-3-yl)acetamide
InChIKey: BJRGHYFCLGZJCG-HNNXBMFYSA-N
SMILES: CC1=NC2=C(C=C(C=C2)N3CC[C@@H](C3)NC(CN4C=NC(C#N)=N4)=O)C=C1
Biological Activity: IID432 is a potent, orally active, and covalent inhibitor of Trypanosoma cruzi topoisomerase II. IID432 shows an EC50 of 8 nM against T. cruzi intracellular amastigotes, exhibits excellent oral bioavailability (52% in rats), favorable ADME properties, and no S1P pathway modulation. IID432 achieves relapse-free cure in a chronic T. cruzi infection mouse model, can be used for the study of Chagas disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
IID432 | 99.19% | IID432 is a potent, orally active, and covalent inhibitor of Trypanosoma cruzi topoisomerase II. IID432 shows an EC50 of 8 nM against T. cruzi intracellular amastigotes, exhibits excellent oral bioavailability (52% in rats), favorable ADME properties, and no S1P pathway modulation. IID432 achieves relapse-free cure in a chronic T. cruzi infection mouse model, can be used for the study of Chagas disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
