Mammea A/BA
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease.
For research use only. We do not sell to patients.
- CAS No.: 5224-54-4
- Formula: C25H26O5
- Molecular Weight:406.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
T. cruzi[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | GI50 |
0.7 μg/mL
Compound: 5
|
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 15787438] |
| NCI-H460 | GI50 |
0.8 μg/mL
Compound: 5
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Cytotoxicity against human H460 cells
Cytotoxicity against human H460 cells
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[PMID: 15787438] |
| PC-3 | IC50 |
2.18 μM
Compound: 13
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Antiproliferative activity against human PC3 cells after 48 hrs
Antiproliferative activity against human PC3 cells after 48 hrs
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[PMID: 21214226] |
| SF-268 | GI50 |
0.6 μg/mL
Compound: 5
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Cytotoxicity against human SF268 cells
Cytotoxicity against human SF268 cells
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[PMID: 15787438] |
| T47D | IC50 |
1.57 μM
Compound: 13
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Antiproliferative activity against human T47D cells after 48 hrs
Antiproliferative activity against human T47D cells after 48 hrs
|
[PMID: 21214226] |
| T47D | IC50 |
3.23 μM
Compound: 13
|
Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
|
[PMID: 21214226] |
| T47D | IC50 |
3.73 μM
Compound: 13
|
Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
|
[PMID: 21214226] |
Chemical Information
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CAS No. 5224-54-4
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Molecular Weight 406.47
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Formula C25H26O5
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SMILES
O=C1C=C(C2=CC=CC=C2)C3=C(O)C(C/C=C(C)\C)=C(O)C(C(CC(C)C)=O)=C3O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)