Search Result

Results for "

epidermal growth factor receptor (EGFR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EGFR (67) IGF-1R (2) VEGFR (4) Akt (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (12) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) BMX Kinase (1) Btk (1) Calcium Channel (2) Carbonic Anhydrase (1) Caspase (3) CDK (1) COX (1) Drug Metabolite (1) ERK (4) FAK (3) HDAC (1) HSP (1) MEK (1) Mitosis (2) MMP (1) mRNA (1) mTOR (1) p38 MAPK (1) PACAP Receptor (2) PERK (1) Phosphatase (3) PI3K (1) PROTACs (2) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Src (4) STAT (1) TAM Receptor (1) Topoisomerase (2) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Cancer (67) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (4) Neurological Disease (2)
Click Chemistry:	Alkynes (6)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: EGFR FGFR GHR VEGFR TGF-β Receptor PDGFR IGF-1R GHSR TGF-beta/Smad Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9905

Cetuximab 50+ Cited Publications C225; IMC-C225	Radionuclide-Drug Conjugates (RDCs) EGFR	Cancer
Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a K_d of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .

HY-P0221

PACAP (1-38), human, ovine, rat 5 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Infection Neurological Disease
PACAP (1-38), human, ovine, rat is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .

HY-13314

Tesevatinib 4 Publications Verification XL-647; EXEL-7647; KD-019	EGFR VEGFR Src	Cancer
Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC₅₀ values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC₅₀=16.1 nM), VEGFR2 (IC₅₀=1.5 nM), and Src (IC₅₀=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity .

HY-144680

BLU-945 ZL-2313	EGFR	Cancer
BLU-945 is a potent, highly selective, reversible and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC) .

HY-132259

Depatuxizumab mafodotin 1 Publications Verification ABT-414	Antibody-Drug Conjugates (ADCs) EGFR	Cancer
Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC). Depatuxizumab mafodotin specifically targets the epidermal growth factor receptor (EGFR). Depatuxizumab mafodotin can be used in the study of glioma, head and neck squamous cell carcinoma, non-small cell lung cancer, epidermoid carcinoma of the skin, and squamous cell carcinoma of the tongue .

HY-N0447

8-Gingerol 5 Publications Verification	TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC₅₀ value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.

HY-19815

Olafertinib CK-101; RX518	EGFR	Cancer
Olafertinib (CK-101) is an orally available, third generation and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Olafertinib selectively inhibits both EGFR-TKI-sensitizing and resistance mutations with minimal activity on wild-type EGFR. Olafertinib can be used in research for non-small cell lung cancer (NSCLC) with EGFR mutations and other advanced malignancies .

HY-48999A

FSK hydrochloride 1 Publications Verification	EGFR	Cancer
FSK hydrochloride is fluorosulfonyloxybenzoyl-L-lysine, which features a long, flexible aryl fluorosulfate-containing side chain that can reach protein sites inaccessible to covalent conjugation. FSK hydrochloride modifies nanomolecules to target epidermal growth factor receptor (EGFR), resulting in irreversibly bound covalent interactions. Through genetically encoded chemical crosslinking, FSK hydrochloride captures unknown enzyme-substrate interactions in living cells, targets residues other than Cys, and mediates crosslinking at the binding periphery. FSK hydrochloride enables the construction of a bioreactive SuFEx system for generating covalent bonds in various proteins both in vitro and in vivo .

HY-18963

Lavendustin A 1 Publications Verification RG-14355	EGFR	Cancer
Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC₅₀ of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis .

HY-138916

PF-06672131	Biochemical Assay Reagents EGFR	Others
PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of *EGFR*. PF-06672131 can be used for activity-based protein profiling studies .

HY-12806

AG1557	EGFR	Cancer
AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC₅₀ value of 8.194 .

HY-100214

EAI001	EGFR	Cancer
EAI001 is a potent, selective mutant **epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC₅₀** value of 24 nM for EGFR ^L858R/T790M. EAI001 can be used for research of cancer .

HY-161633

PROTAC EGFR degrader 11	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a K_i of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <100 nM.

HY-115605

CN009543V	EGFR p38 MAPK ERK Phosphatase	Cancer
CN009543V is an epidermal growth factor receptor (EGFR) agonist. CN009543V enhances tyrosine phosphorylation of EGFR at Tyr1068 and Tyr1173, thereby activating the MAPK/ERK cascade. CN009543V inhibits the activity of PTP-1B in MDA MB468 cells. CN009543V can be used in cancer research .

HY-100499

Tyrphostin AG 528 1 Publications Verification Tyrphostin B66; AG 528	EGFR	Cancer
Tyrphostin AG 528 is an inhibitor of *EGFR* and ErbB2 with IC₅₀s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC₅₀s of 4.9 μM for **epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2** . Tyrphostin AG 528 is also an anticancer agent .

HY-19985A

(3S,4S)-PF-06459988	EGFR	Cancer
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against *EGFR* wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling .

HY-P1085

Epidermal Growth Factor Receptor Peptide (985-996)	EGFR	Cancer
Epidermal Growth Factor Receptor Peptide (985-996) is an amino acid peptide fragment derived from positions 985-996 in epidermal growth factor receptor (EGFR) .

HY-U00002

ZD-4190	VEGFR EGFR	Cancer
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.

HY-15772S3

Asandeutertinib asandeutertinibum; Osimertinib-d₃; AZD-9291-d₃	EGFR	Cancer
Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .

HY-176279

Hsp90-IN-42	HSP	Cancer
Hsp90-IN-42 (Compound 13l) is a potent heat shock protein 90 (Hsp90) inhibitor (IC₅₀=15.65 nM). Hsp90-IN-42 reduces the stability of the epidermal growth factor receptor (EGFR), suppressing the activation of the EGFR-Akt signaling pathway, inducing G0/G1 phase arrest in colorectal cancer cells (such as HT-29 cells), and slightly triggering apoptosis. Hsp90-IN-42 also inhibits cell proliferation and migration by down-regulating the expression of CDK12, CDK13, and Bcl-2 proteins, and up-regulating the expression of Bax protein. Hsp90-IN-42 is promising for research of colorectal cancer .

HY-117852

CGP-59326 TRX-13	EGFR Tyrosinase	Cancer
CGP-59326 (TRX-13) is a highly potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC₅₀=0.027 μM). CGP-59326 blocks the EGFR signaling pathwa, demonstrating highly selective inhibition of EGFR-dependent tumor cells. CGP-59326 is promising for research of cancers .

HY-129510

4-Methyl erlotinib	EGFR Mitosis	Cancer
4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers .

HY-19909

NRC-2694	EGFR	Cancer
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. NRC-2694 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139300A

Epitinib succinate HMPL-813 succinate	EGFR	Cancer
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101522

CHMFL-EGFR-202	EGFR BMX Kinase Btk MEK	Cancer
CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC₅₀s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL-EGFR-202 exhibits ～10-fold selectivity for EGFR L858R/T790M against the EGFR wild-type in cells. CHMFL-EGFR-202 adopts a covalent “DFG-in-C-helix-out” inactive binding conformation with EGFR, with strong antiproliferative effects against EGFR mutant-driven nonsmall-cell lung cancer (NSCLC) cell lines .

HY-144049

EGFR-IN-32	EGFR	Cancer
EGFR-IN-32 is a potent inhibitor of *EGFR. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-32 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185297A1, compound 2) .

HY-164527

Si306	Src FAK EGFR	Cancer
Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM) .

HY-174231

EGFR-IN-163	EGFR Apoptosis	Cancer
EGFR-IN-163 (Compound 13) is a competitive epidermal growth factor receptor (EGFR) inhibitor (IC₅₀=0.079 μM, selective for HER-2 inhibition). EGFR-IN-163 induces tumor cell apoptosis and cell cycle arrest at G₂/M phase. EGFR-IN-163 is promising for research of estrogen receptor-positive (ER+) breast cancer .

HY-161632

PROTAC EGFR degrader 10	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 10 binds CRBN-DDB1 with a K_i of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <150 nM .

HY-120412

SKLB188	EGFR Apoptosis	Cancer
SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC₅₀=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors .

HY-178440

EGFR/COX-2-IN-2	EGFR COX Apoptosis	Inflammation/Immunology Cancer
EGFR/COX-2-IN-2 (Compound 10a) is a dual inhibitor targeting epidermal growth factor receptor (EGFR) (IC₅₀= 6.0 μM) and cyclooxygenase-2 (COX-2) (IC₅₀=50 μM). EGFR/COX-2-IN-2 induces S-phase cell cycle arrest and apoptosis. EGFR/COX-2-IN-2 is promising for research of cancers and inflammation-related diseases .

HY-174232

EGFR/CA-IX-IN-1	EGFR Carbonic Anhydrase Caspase	Cancer
EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC₅₀ values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC₅₀ values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer .

HY-174841

EGFR/HER2-IN-19	EGFR	Cancer
EGFR/HER2-IN-19 (Compound L1) is a dual inhibitor against epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). EGFR/HER2-IN-19 is promising for research of cancers driven by EGFR/HER2 .

HY-160613

EGFR/HER2-IN-11	EGFR	Cancer
EGFR/HER2-IN-11 (compound 20) is an orally active dual inhibitor for human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), with IC₅₀s of 7.7 and 22 nM, respectively. EGFR/HER2-IN-11 exhibits antitumor efficacy and inhibits proliferation against cancer cells BT-474 with GI₅₀ of 601 nM .

HY-169755

Tyrphostin 63	EGFR	Cancer
Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor with IC₅₀ and K_i values are 375 and 123 μM, respectively .

HY-172623

EGFR/HER2-IN-17	EGFR Caspase Apoptosis Bcl-2 Family	Cancer
EGFR/HER2-IN-17 (Compound 7h) is a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). EGFR/HER2-IN-17 inhibits cancer cell proliferation. EGFR/HER2-IN-17 interacts with the binding pockets of EGFR and HER2, activating caspase-3 and caspase-8, and decreases the expression of Bcl-2, thereby inducing apoptosis. EGFR/HER2-IN-17 is promising for research of cancers .

HY-115716

EGFR-IN-17	EGFR	Cancer
EGFR-IN-17 is a potent and selective inhibitor of the **epidermal growth factor receptor ( IC₅₀** 0.0002 μM) to overcome C797S-mediated resistance.

HY-144048

EGFR-IN-31	EGFR	Cancer
EGFR-IN-31 is a potent inhibitor of *EGFR. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-31 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185298A1, compound 2) .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1799A

[pTyr5] EGFR (988-993) TFA	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-162099

VEGFR-IN-4	EGFR	Cancer
VEGFR-IN-4 (Compound 6e) is an epidermal growth factor receptor (EGFR) inhibitor. VEGFR-IN-4 has potent antiproliferative activity with an IC₅₀ value of 24.6nM against HCC827 cells .

HY-145867

EGFR-IN-45	Topoisomerase EGFR CDK Apoptosis	Cancer
EGFR-IN-45 is a potent epidermal growth factor receptor (EGFR) pan inhibitor, with IC₅₀s of 0.4 µM and 1.6 µM for *EGFR* and CDK2, respectively. EGFR-IN-45 also inhibit Topo I and Topo II. EGFR-IN-45 arrests cancer cells in the pre-G1 phase and induces apoptosis .

HY-162482

EGFR kinase inhibitor 5	EGFR Apoptosis	Inflammation/Immunology Cancer
EGFR kinase inhibitor 5 (Compound 4c) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with IC₅₀ of 18.35 μM. EGFR kinase inhibitor 5 induces apoptosis. EGFR kinase inhibitor 5 exhibits anticancer and anti-inflammatory activity with low toxicity (LD₅₀ range: 500-2000 mg/kg) .

HY-162483

EGFR kinase inhibitor 6	EGFR Apoptosis	Inflammation/Immunology Cancer
EGFR kinase inhibitor 6 (Compound 4b) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with IC₅₀ of 24.34 μM. EGFR kinase inhibitor 6 induces apoptosis. EGFR kinase inhibitor 6 exhibits anticancer and anti-inflammatory activity with low toxicity (LD₅₀ range: 500-2000 mg/kg) .

HY-144050

EGFR-IN-33	EGFR	Cancer
EGFR-IN-33 is a potent inhibitor of *EGFR. EGFR-IN-33 is an anti-tumor agent with low toxic side effects. EGFR-IN-33 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-33 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 13) .

HY-144052

EGFR-IN-35	EGFR	Cancer
EGFR-IN-35 is a potent inhibitor of *EGFR. EGFR-IN-35 is an anti-tumor agent with low toxic side effects. EGFR-IN-35 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-35 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 11) .

HY-144051

EGFR-IN-34	EGFR	Cancer
EGFR-IN-34 is a potent inhibitor of *EGFR. EGFR-IN-34 is an anti-tumor agent with low toxic side effects. EGFR-IN-35 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-34 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 12) .

HY-144056

EGFR-IN-39	EGFR	Cancer
EGFR-IN-39 is a potent inhibitor of *EGFR. EGFR-IN-39 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-39 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 2) .

HY-144054

EGFR-IN-37	EGFR	Cancer
EGFR-IN-37 is a potent inhibitor of *EGFR. EGFR-IN-37 is an anti-tumor agent with low toxic side effects. EGFR-IN-39 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-37 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 7) .

HY-144055

EGFR-IN-38	EGFR	Cancer
EGFR-IN-38 is a potent inhibitor of *EGFR. EGFR-IN-38 is an anti-tumor agent with low toxic side effects. EGFR-IN-33 is an acrylamide derivative compound. Overexpression and mutation of the epidermal* growth factor receptor (EGFR) has been clearly demonstrated to lead to uncontrollable cell growth and is associated with the progression of most cancer diseases, especially NSCLC. EGFR-IN-38 has the potential for the research of diseases associated with EGFR mutations (extracted from patent WO2021185348A1, compound 4) .

Cat. No.	Product Name

HY-L075

Anti-Lung Cancer Compound Library

2,886 compounds

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers.

As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy.

MCE offers a unique collection of 2,886 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P0221

PACAP (1-38), human, ovine, rat 5 Publications Verification Pituitary Adenylate Cyclase Activating Polypeptide 38	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Infection Neurological Disease
PACAP (1-38), human, ovine, rat is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research .

HY-P1085

Epidermal Growth Factor Receptor Peptide (985-996)	EGFR	Cancer
Epidermal Growth Factor Receptor Peptide (985-996) is an amino acid peptide fragment derived from positions 985-996 in epidermal growth factor receptor (EGFR) .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1799A

[pTyr5] EGFR (988-993) TFA	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P0221A

PACAP (1-38), human, ovine, rat TFA Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA	PACAP Receptor ERK EGFR Reactive Oxygen Species (ROS) Calcium Channel	Neurological Disease
PACAP (1-38), human, ovine, rat TFA is a PAC₁ receptor agonist. PACAP (1-38), human, ovine, rat TFA binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat TFA increases the α-secretase activity. PACAP (1-38), human, ovine, rat TFA elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat TFA can be used for neurotrophic and neuroprotective research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9905

Cetuximab 50+ Cited Publications C225; IMC-C225	Radionuclide-Drug Conjugates (RDCs) EGFR	Cancer
Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a K_d of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0447

8-Gingerol 5 Publications Verification	Zingiber officinale Roscoe Monophenols Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae Cancer	TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP
8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC₅₀ value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.

HY-18963

Lavendustin A 1 Publications Verification RG-14355	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Source Classification Cancer	EGFR
Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC₅₀ of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis .

HY-18963R

Lavendustin A (Standard) RG-14355 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Phenols Polyphenols Source Classification	Reference Standards EGFR
Lavendustin A (Standard) is the analytical standard of Lavendustin A. This product is intended for research and analytical applications. Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2].

Species:	Human (28) Rhesus Macaque (3) Rat (1) Mouse (4) Cynomolgus (2) Canine (1)
Tag:	His (26) Strep (6) Tag Free (3) Avi (3) Myc (1) GST (14) Fc (7)
Source:	HEK293 (19) sf9 insect cells (5) Sf9 insect cells (15)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70189

	EGFR vIII Protein, Human (HEK293, His) rHuepidermal growth factor receptor/EGFR vIII, His; epidermal growth factor receptor; EGFR; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EGFR	Human	HEK293
	The EGFRvIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor. It acts on the cell surface, binds to epidermal growth factor, triggers receptor dimerization and tyrosine autophosphorylation, and promotes cell proliferation. EGFR vIII Protein, Human (HEK293, His) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72986

	EGFR Protein, Canine (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Canine	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein participate in the NF-kappa-B signaling pathway. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein, Canine (sf9, His) is the recombinant canine-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P72988

	EGFR Protein, Mouse (HEK293, Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72990

	EGFR Protein, Rat (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rat	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family.EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways.EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity.EGFR Protein, Rat (HEK293, His) is the recombinant rat-derived EGFR protein, expressed by HEK293 , with C-His labeled tag.

HY-P75259

	EGFR Protein, Cynomolgus (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Cynomolgus	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75260

	EGFR Protein, Cynomolgus (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Cynomolgus	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P72989

	EGFR Protein, Mouse (HEK293, His, solution) 1 Publications Verification epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75257

	EGFR Protein, Rhesus Macaque (HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75256

	EGFR Protein, Rhesus Macaque (sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75258

	EGFR Protein, Rhesus Macaque (HEK293, Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72987

	EGFR Protein, Human (Active, sf9, His-GST) 2 Publications Verification epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells
	EGFR is a transmembrane glycoprotein. EGFR binds to ligands, triggering receptor dimerization, inducing intracellular TK domain autophosphorylation, activating downstream Ras/MAPK, PI3K/Akt and other signaling pathways, and regulating cell proliferation, survival, migration and angiogenesis. EGFR Protein, Human (sf9, His-GST) is a recombinant EGFR protein expressed by Sf9 insect cells with N-His, N-GST tags.

HY-P704578

	EGFR Protein, Human (621a.a, HEK293) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293) is the recombinant human-derived EGFR protein, expressed by HEK293, with tag free.

HY-P705251

	EGFR Protein, Mouse (Biotinylated, HEK293, Fc-Avi) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293

HY-P705252

	EGFR Protein, Mouse (Biotinylated, HEK293, His-Avi) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Mouse	HEK293

HY-P74177

	EGFR Protein, Human (621a.a, HEK293, Fc) 1 Publications Verification epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73517

	EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-His labeled tag.

HY-P704197

	EGFR Protein, Human (Active, L861Q, sf9, GST) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (L861Q, sf9, GST) is the recombinant human-derived EGFR protein, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P704576

	EGFR Protein, Human (621a.a, HEK293, Llama Fc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, Llama Fc) is the recombinant human-derived EGFR protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P704574

	FITC-Labeled EGFR Protein, Human (621a.a, HEK293, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. FITC-Labeled EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived FITC-Labeled EGFR protein, expressed by HEK293, with C-His labeled tag.

HY-P705016

	EGFR Protein, Human (Biotinylated, 621a.a, HEK293, Fc-Avi) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293

HY-P705815

	EGFR Protein, Human (Active, G719C, sf9, His-GST) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	sf9 insect cells

HY-P700409

	EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag.

HY-P705811

	EGFR Protein, Human (Active, G719S, sf9, Strep-GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	sf9 insect cells

HY-P700693

	CLEC14A Protein, Human (HEK293, His) epidermal growth factor receptor 5; EGFR-5; EGFR 5; EGFR5; C14orf27; UNQ236; PRO269; CEG1	Human	HEK293
	CLEC14A is a type I transmembrane protein belonging to the C-type lectin superfamily that mediates intercellular adhesion, inflammatory response, and apoptosis. CLEC14A is upregulated in hepatocellular carcinoma and may serve as a potential diagnostic biomarker. CLEC14A Protein, Human (HEK293, His) is the recombinant human-derived CLEC14A protein, expressed by HEK293 , with C-His labeled tag.

HY-P705812

	EGFR Protein, Human (Active, A763_Y764insFHEA, sf9, Strep-GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	sf9 insect cells

HY-P705813

	EGFR Protein, Human (Active, A763_Y764insFQEA, sf9, Strep-GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	sf9 insect cells

HY-P70608

	EGFR vIII Protein, Human (HEK293, Fc) 1 Publications Verification epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR vIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor. It acts on the cell surface, binds to epidermal growth factor, triggers receptor dimerization and tyrosine autophosphorylation, and promotes cell proliferation. EGFR vIII Protein, Human (HEK293, Fc) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P702831

	EGFR Protein, Human (Active, C797S, T790M, L858R, sf9, GST) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (C797S, T790M, L858R, sf9, GST) is the recombinant human-derived EGFR, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P702832

	EGFR Protein, Human (Active, T790M, L858R, sf9, Strep II, GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (T790M, L858R, sf9, Strep II, GST, His) is the recombinant human-derived EGFR, expressed by Sf9 insect cells, with C-8*His, N-GST, N-Strep II labeled tag.

HY-P70613

	EGFR Protein, Human (621a.a, HEK293, His) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705601

	EGFR Protein, Human (Active, ΔE746-A750, T790M, L858R, sf9, GST) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P706036

	EGFR Protein, Human (Active, 327a.a, sf9) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P705562

	EGFR Protein, Human (Active, L858R, sf9, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EC:2.7.10.1	Human	Sf9 insect cells

HY-P706038

	EGFR Protein, Human (Active, C797S, sf9, His-GST) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P706040

	EGFR Protein, Human (Active, T790M, sf9, His-GST) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P705814

	EGFR Protein, Human (Active, G696-G1022, ΔE746-A750, T790M, C797S, sf9, Strep-GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1	Human	sf9 insect cells

HY-P706037

	EGFR Protein, Human (Active, C797S, L858R, sf9) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P706039

	EGFR Protein, Human (Active, T790M, C797S, sf9, His-GST) epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1	Human	Sf9 insect cells

HY-P705561

	EGFR Protein, Human (Active, ΔE746-A750, T790M, C797S, sf9, Strep-GST, His) epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; EC:2.7.10.1	Human	Sf9 insect cells

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-15772S3

Asandeutertinib
Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect .

Host:	Mouse (6) Rabbit (15)
Reactivity:	Human (21) Rat (5) Mouse (7) Monkey (3)
Application:	IHC-P (14) ICC/IF (14) mIHC (1) IF-Tissue (4) IP (9) IHC-F (6) WB (21) FC (2) ELISA (2)
Isotype:	IgG (15) IgG1 (4) IgG2a (1)
Conjugation:	Non-conjugated (21) Biotin (4)
Clonality:	Monoclonal (9) Recombinant (4)
Modification:	Phosphorylated (10) Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80648

	EGFR Antibody (YA775) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IP	Human, Monkey
	EGFR Antibody (YA775) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EGFR.

HY-P86375

	EGFR Antibody (YA6067) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EGFR Antibody (YA6067) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EGFR.

HY-P85843

	EGFR Antibody (YA5535) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	IHC-P, WB, ICC/IF, ELISA	Human
	EGFR Antibody (YA5535) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to EGFR.

HY-P810668

	Phospho-EGFR (Tyr1148) Antibody EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF	Human
	Phospho-EGFR (Tyr1148) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-EGFR (Tyr1148).

HY-P80648A

	EGFR Antibody (YA775)(PBS only) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IP	Human, Monkey
	EGFR Antibody (YA775) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EGFR.

HY-P80808

	Phospho-EGFR (Tyr1068) Antibody (YA207) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF	Human
	Phospho-EGFR (Tyr1068) Antibody (YA207) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1068).

HY-P80809

	Phospho-EGFR (Tyr1092) Antibody (YA206) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-P	Human, Mouse, Rat
	Phospho-EGFR (Tyr1092) Antibody (YA206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1092).

HY-P80810

	Phospho-EGFR (Tyr1173) Antibody (YA205) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Phospho-EGFR (Tyr1173) Antibody (YA205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1173).

HY-P810672

	Phospho-EGFR (Thr669) Antibody (YA9931) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IP	Human, Mouse, Rat
	Phospho-EGFR (Thr669) Antibody (YA9931) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Thr669).

HY-P810669

	Phospho-EGFR (Tyr1092) Antibody (YA9928) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IF-Tissue, IHC-P	Human, Mouse
	Phospho-EGFR (Tyr1092) Antibody (YA9928) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Tyr1092).

HY-P810670

	Phospho-EGFR (Tyr1045) Antibody (YA9929) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, FC	Human
	Phospho-EGFR (Tyr1045) Antibody (YA9929) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Tyr1045).

HY-P810671

	Phospho-EGFR (Tyr845) Antibody (YA9930) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB	Human
	Phospho-EGFR (Tyr845) Antibody (YA9930) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Tyr845).

HY-P810673

	Phospho-EGFR (Ser695) Antibody (YA9932) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IF-Tissue	Human
	Phospho-EGFR (Ser695) Antibody (YA9932) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Ser695).

HY-P810674

	Phospho-EGFR (Tyr1173) Antibody (YA9933) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IHC-P, IP	Human, Mouse
	Phospho-EGFR (Tyr1173) Antibody (YA9933) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-EGFR (Tyr1173).

HY-P80808A

	Phospho-EGFR (Tyr1068) Antibody (YA207)(PBS only) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF	Human
	Phospho-EGFR (Tyr1068) Antibody (YA207) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1068).

HY-P80809A

	Phospho-EGFR (Tyr1092) Antibody (YA206)(PBS only) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-P	Human, Mouse, Rat
	Phospho-EGFR (Tyr1092) Antibody (YA206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1092).

HY-P80810A

	Phospho-EGFR (Tyr1173) Antibody (YA205)(PBS only) EGFR; ERBB; ERBB1; HER1; epidermal growth factor receptor; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Phospho-EGFR (Tyr1173) Antibody (YA205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EGFR (Tyr1173).

HY-P86718

	EGFR Antibody (YA6410) EGFR; Avian erythroblastic leukemia viral(v erb b) oncogene homolog; Avian erythroblastic leukemia viral(verbb) oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; epidermal growth factor receptor(avian erythroblastic leukemia viral(v erb b) oncogene homolog); epidermal growth factor receptor(erythroblastic leukemia viral(v erb b) oncogene homolog avian); epidermal growth factor receptor; erbb 1; Erbb; Erbb1; HER1; mENA; Oncogene ERBB; PIG61; receptor tyrosine protein kinase ErbB 1; receptor tyrosine protein kinase ErbB1; Urogastrone; wa2; Wa5; EGFR_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	EGFR Antibody (YA6410) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EGFR.

HY-P85600

	EGFR Antibody (YA5292) Avian erythroblastic leukemia viral; v erb b; oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; EGFR_HUMAN; epidermal growth factor receptor; avian erythroblastic leukemia viral; v erb b; oncogene homolog; epidermal growth factor receptor; erythroblastic leukemia viral; v erb b; oncogene homolog avian; epidermal growth factor receptor; erbb 1; Erbb; Erbb1; ERBB1; Errp; HER1; mENA; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine protein kinase ErbB 1; receptor tyrosine-protein kinase ErbB-1; Urogastrone; wa2; Wa5.	WB, IHC-P, ICC/IF, IP	Human, Monkey
	EGFR Antibody (YA5292) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to EGFR.

HY-P86718A

	EGFR Antibody (YA6410)(PBS only) EGFR; Avian erythroblastic leukemia viral(v erb b) oncogene homolog; Avian erythroblastic leukemia viral(verbb) oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; epidermal growth factor receptor(avian erythroblastic leukemia viral(v erb b) oncogene homolog); epidermal growth factor receptor(erythroblastic leukemia viral(v erb b) oncogene homolog avian); epidermal growth factor receptor; erbb 1; Erbb; Erbb1; HER1; mENA; Oncogene ERBB; PIG61; receptor tyrosine protein kinase ErbB 1; receptor tyrosine protein kinase ErbB1; Urogastrone; wa2; Wa5; EGFR_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	EGFR Antibody (YA6410) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EGFR.

HY-P80116

	EGFR Antibody (YA468) 1 Publications Verification Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody; Cell growth inhibiting protein 40 antibody; Cell proliferation inducing protein 61 antibody; EGF R antibody; EGFR antibody; EGFR_HUMAN antibody; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody; epidermal growth factor receptor antibody; erb-b2 receptor tyrosine kinase 1 antibody; ERBB antibody; ERBB1 antibody; Errp antibody; HER1 antibody; mENA antibody; NISBD2 antibody; Oncogen ERBB antibody; PIG61 antibody; Proto-oncogene c-ErbB-1 antibody; receptor tyrosine protein kinase ErbB 1 antibody; receptor tyrosine-protein kinase ErbB-1 antibody; SA7 antibody; Species antigen 7 antibody; Urogastrone antibody; v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody; wa2 antibody; Wa5 antibody	WB, IHC-P, ICC/IF, IP, FC, mIHC	Human, Mouse, Rat
	EGFR Antibody (YA468) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EGFR.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-129510

4-Methyl erlotinib		Alkynes
4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers .

HY-19909

NRC-2694		Alkynes
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. NRC-2694 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139300A

Epitinib succinate HMPL-813 succinate		Alkynes
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150781

EGFR-IN-71		Alkynes
EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC₅₀ values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma . EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-150782

UNC-CA359		Alkynes
UNC-CA359 is a potent **epidermal growth factor receptor** (EGFR) inhibitor, with an IC₅₀ value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research . UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-181701

EGFR-IN-202		Alkynes
EGFR-IN-202 is an epidermal growth factor receptor (EGFR) inhibitor that selectively targets EGFR exon 20 insertion mutations. EGFR-IN-202 can be used in research related to non-small cell lung cancer .

Cat. No.	Product Name		Classification

HY-174721

Human EGFR mRNA		mRNA
Human EGFR mRNA encodes the human epidermal growth factor receptor (EGFR) protein, a member of the protein kinase superfamily. IGF1R plays a critical role in transformation events. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks