EGFR/HER2-IN-19
EGFR/HER2-IN-19 (Compound L1) is a dual inhibitor against epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). EGFR/HER2-IN-19 is promising for research of cancers driven by EGFR/HER2.
For research use only. We do not sell to patients.
- CAS No.: 2229835-58-7
- Formula: C33H41ClFN7O3
- Molecular Weight:638.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
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HER2 |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.958 μM
Compound: 1f
|
Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
Antiproliferative activity against human A431 cells after 72 hrs by MTT assay
|
[PMID: 30508379] |
| A549 | IC50 |
3.4 μM
Compound: 1f
|
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 30508379] |
| L929 | IC50 |
2.74 μM
Compound: 1f
|
Cytotoxicity against mouse L929 cells assessed as cell growth inhibition after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as cell growth inhibition after 72 hrs by MTT assay
|
[PMID: 30508379] |
Chemical Information
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CAS No. 2229835-58-7
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Molecular Weight 638.18
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Formula C33H41ClFN7O3
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SMILES
COC(C=C1N=CN=C(C1=C2)NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=C2OCCCN5CCNCCNCCNCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)