FSK hydrochloride
Based on 1 publication(s) in Google Scholar
FSK hydrochloride is fluorosulfonyloxybenzoyl-L-lysine, which features a long, flexible aryl fluorosulfate-containing side chain that can reach protein sites inaccessible to covalent conjugation. FSK hydrochloride modifies nanomolecules to target epidermal growth factor receptor (EGFR), resulting in irreversibly bound covalent interactions. Through genetically encoded chemical crosslinking, FSK hydrochloride captures unknown enzyme-substrate interactions in living cells, targets residues other than Cys, and mediates crosslinking at the binding periphery. FSK hydrochloride enables the construction of a bioreactive SuFEx system for generating covalent bonds in various proteins both in vitro and in vivo.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 3033987-42-4
- Formula: C13H18ClFN2O6S
- Molecular Weight:384.81
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) FSK hydrochloride
MoreAll EGFR Isoforms
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Biological Activity
FSK enables efficient intermolecular cross-linking of ecGST homodimers in E. coli[1].
FSK mediates intermolecular cross-linking by reacting with the proximal His, Tyr, and Lys residues of the sjGST homodimer in E. coli[1].
FSK efficiently mediates intermolecular cross-linking between Trx and PAPS reductase in E. coli[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033987-42-4
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Appearance Solid
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Molecular Weight 384.81
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Formula C13H18ClFN2O6S
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Color White to off-white
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SMILES
O=C(NCCCC[C@H](N)C(O)=O)C1=CC=C(OS(F)(=O)=O)C=C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 200 mg/mL (519.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 62.5 mg/mL (162.42 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5987 mL | 12.9934 mL | 25.9869 mL | 64.9671 mL |
| 5 mM | 0.5197 mL | 2.5987 mL | 5.1974 mL | 12.9934 mL | |
| 10 mM | 0.2599 mL | 1.2993 mL | 2.5987 mL | 6.4967 mL | |
| 15 mM | 0.1732 mL | 0.8662 mL | 1.7325 mL | 4.3311 mL | |
| 20 mM | 0.1299 mL | 0.6497 mL | 1.2993 mL | 3.2484 mL | |
| 25 mM | 0.1039 mL | 0.5197 mL | 1.0395 mL | 2.5987 mL | |
| 30 mM | 0.0866 mL | 0.4331 mL | 0.8662 mL | 2.1656 mL | |
| 40 mM | 0.0650 mL | 0.3248 mL | 0.6497 mL | 1.6242 mL | |
| 50 mM | 0.0520 mL | 0.2599 mL | 0.5197 mL | 1.2993 mL | |
| 60 mM | 0.0433 mL | 0.2166 mL | 0.4331 mL | 1.0828 mL | |
| 80 mM | 0.0325 mL | 0.1624 mL | 0.3248 mL | 0.8121 mL | |
| 100 mM | 0.0260 mL | 0.1299 mL | 0.2599 mL | 0.6497 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
FSK hydrochloride Related Classifications
HY-48999A Related Classifications
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