3033987-42-4
Chemical Structure
FSK hydrochloride
- CAS No.: 3033987-42-4
- Formula:C13H18ClFN2O6S
- Molecular Weight:384.81
InChIKey: WDAPBEYTBHLADN-MERQFXBCSA-N
SMILES: O=C(NCCCC[C@H](N)C(O)=O)C1=CC=C(OS(F)(=O)=O)C=C1.[H]Cl
Biological Activity: FSK hydrochloride is fluorosulfonyloxybenzoyl-L-lysine, which features a long, flexible aryl fluorosulfate-containing side chain that can reach protein sites inaccessible to covalent conjugation. FSK hydrochloride modifies nanomolecules to target epidermal growth factor receptor (EGFR), resulting in irreversibly bound covalent interactions. Through genetically encoded chemical crosslinking, FSK hydrochloride captures unknown enzyme-substrate interactions in living cells, targets residues other than Cys, and mediates crosslinking at the binding periphery. FSK hydrochloride enables the construction of a bioreactive SuFEx system for generating covalent bonds in various proteins both in vitro and in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FSK hydrochloride | 99.97% | FSK hydrochloride is fluorosulfonyloxybenzoyl-L-lysine, which features a long, flexible aryl fluorosulfate-containing side chain that can reach protein sites inaccessible to covalent conjugation. FSK hydrochloride modifies nanomolecules to target epidermal growth factor receptor (EGFR), resulting in irreversibly bound covalent interactions. Through genetically encoded chemical crosslinking, FSK hydrochloride captures unknown enzyme-substrate interactions in living cells, targets residues other than Cys, and mediates crosslinking at the binding periphery. FSK hydrochloride enables the construction of a bioreactive SuFEx system for generating covalent bonds in various proteins both in vitro and in vivo. | ||||||||||||||||||||
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Keywords
