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Cat. No.: HY-162482

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EGFR kinase inhibitor 5

EGFR kinase inhibitor 5 (Compound 4c) is an orally active inhibitor for epidermal growth factor receptor (EGFR) kinase, with IC₅₀ of 18.35 μM. EGFR kinase inhibitor 5 induces apoptosis. EGFR kinase inhibitor 5 exhibits anticancer and anti-inflammatory activity with low toxicity (LD₅₀ range: 500-2000 mg/kg).

For research use only. We do not sell to patients.

Formula: C₂₁H₁₆BrN₃OS₂
Molecular Weight:470.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

EGFR kinase inhibitor 5 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 18.35 μM (EGFR Kinase)

All EGFR Isoforms :

In Vitro

EGFR kinase inhibitor 5 (0-80 μM, 72 h) inhibits migration of cancer cell A549, and exhibits anticancer activity against cancer cell A549, MCF7 and HCT116, with IC₅₀s of 10.74, 18.73 and 23.22 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

A549
Concentration:

0-30 μM
Incubation Time:

24 h
Result:

Inhibited cell migration.

In Vivo

EGFR kinase inhibitor 5 (14.77 mg/kg, p.o., 15 days) exhibits anti-inflammatory efficacy in carrageenan induced rat paw edema model, with low ulcerogenic potential and lipid peroxidation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan-induced hind paw edema in Wistar rats model^[1]
Dosage:

0.0314 mmol/kg
Administration:

p.o., 15 days
Result:

Inhibited 80.17% paw edema.

Chemical Information

Molecular Weight 470.41
Formula C₂₁H₁₆BrN₃OS₂
SMILES

O=C1C(C)SC(C2=C(C3=CC=CC=C3)N=C4N2C=CS4)N1C5=CC=C(Br)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kamboj P, et al., Design, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents. Sci Rep. 2024 Apr 11;14(1):8457. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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EGFR kinase inhibitor 5

All EGFR Isoforms