2. JAK/STAT Signaling Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. EGFR Mitosis
  4. 4-Methyl erlotinib

4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers.

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4-Methyl erlotinib

4-Methyl erlotinib Chemical Structure

CAS No. : 1346601-52-2

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Based on 1 publication(s) in Google Scholar

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4-Methyl erlotinib Related Antibodies

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Description

4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers[1].

Molecular Weight

407.46

Formula

C23H25N3O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C#CC1=CC(NC2=C3C=C(OCCOC)C(OCCOC)=CC3=NC=N2)=CC=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (40.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4542 mL 12.2711 mL 24.5423 mL
5 mM 0.4908 mL 2.4542 mL 4.9085 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4542 mL 12.2711 mL 24.5423 mL 61.3557 mL
5 mM 0.4908 mL 2.4542 mL 4.9085 mL 12.2711 mL
10 mM 0.2454 mL 1.2271 mL 2.4542 mL 6.1356 mL
15 mM 0.1636 mL 0.8181 mL 1.6362 mL 4.0904 mL
20 mM 0.1227 mL 0.6136 mL 1.2271 mL 3.0678 mL
25 mM 0.0982 mL 0.4908 mL 0.9817 mL 2.4542 mL
30 mM 0.0818 mL 0.4090 mL 0.8181 mL 2.0452 mL
40 mM 0.0614 mL 0.3068 mL 0.6136 mL 1.5339 mL
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4-Methyl erlotinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methyl erlotinib1346601-52-2EGFRMitosisEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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