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Results for "

influenza H1N1 viruses

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Influenza Virus (69) Antibiotic (1) Apoptosis (3) Bacterial (2) CDK (2) DNA/RNA Synthesis (3) Drug Derivative (1) Endogenous Metabolite (1) Enterovirus (1) Environmental Pollutants (1) Ferroptosis (1) Glutathione Peroxidase (1) Glutathione S-transferase (1) HSP (1) HSV (3) IFNAR (3) iGluR (2) Interleukin Related (2) Isotope-Labeled Compounds (1) JAK (1) JNK (2) Keap1-Nrf2 (2) NF-κB (1) p38 MAPK (3) PROTACs (1) Protein Arginine Deiminase (1) Reactive Oxygen Species (ROS) (3) Reference Standards (5) RSV (3) SARS-CoV (3) Ser/Thr Protease (1) SOD (2) STAT (1) STING (2) Toll-like Receptor (TLR) (1) β-glucuronidase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (73) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (3)

By Targets:

Influenza Virus (69)

Antibiotic (1)

Apoptosis (3)

Bacterial (2)

CDK (2)

DNA/RNA Synthesis (3)

Drug Derivative (1)

Endogenous Metabolite (1)

Enterovirus (1)

Environmental Pollutants (1)

Ferroptosis (1)

Glutathione Peroxidase (1)

Glutathione S-transferase (1)

HSP (1)

HSV (3)

IFNAR (3)

iGluR (2)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

JAK (1)

JNK (2)

Keap1-Nrf2 (2)

NF-κB (1)

p38 MAPK (3)

PROTACs (1)

Protein Arginine Deiminase (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (5)

RSV (3)

SARS-CoV (3)

Ser/Thr Protease (1)

SOD (2)

STAT (1)

STING (2)

Toll-like Receptor (TLR) (1)

β-glucuronidase (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (2)

Infection (73)

Inflammation/Immunology (7)

Metabolic Disease (2)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Influenza Virus

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10964

Vadimezan Maximum Cited Publications 71 Publications Verification DMXAA; ASA-404	STING IFNAR Influenza Virus	Infection Cancer
Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus *H1N1-PR8* activities.

HY-13317

Oseltamivir 45+ Cited Publications GS 4104	Influenza Virus	Infection Cancer
Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-107201

β-Cyclodextrin 5+ Cited Publications Betadex	Environmental Pollutants Influenza Virus	Infection
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus *H1N1* activities.

HY-N0638

Dendrobine 5+ Cited Publications	Influenza Virus JNK p38 MAPK Apoptosis CDK Keap1-Nrf2 SOD Reactive Oxygen Species (ROS)	Infection Neurological Disease Inflammation/Immunology Cancer
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against **influenza A viruses, with IC₅₀*s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2* signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties .

HY-175469

VNT-101	Influenza Virus	Infection
VNT-101 is an orally active influenza A (IAV) inhibitor. VNT-101 disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex, with potent antiviral activity across multiple influenza A subtypes. VNT-101 exhibits EC₅₀ values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay. VNT-101 demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. VNT-101 can be used for the study of influenza A infection .

HY-P99620

Firivumab CT-P22; CT120	Influenza Virus	Infection
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .

HY-126136

ML303	Influenza Virus	Infection
ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC₉₀ = 155 nM), with an EC₅₀ of 0.7 μM for Influenza A virus H1N1 .

HY-13317S

Oseltamivir-d3	Influenza Virus	Infection
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-P991059

VIS-410	Influenza Virus	Infection
VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits **influenza virus** replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as *H1N1, H3N2, H5N1, and H7N9* (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride	iGluR Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1_A/2B NMDA receptors (IC₅₀ = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple *H1N1* subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and *H1N1* strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), **influenza virus, and H5N1** influenza .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Influenza Virus	Infection Inflammation/Immunology
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-137334

Neuraminidase-IN-1	Influenza Virus	Infection
Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC₅₀ of 0.21 μM. Neuraminidase-IN-1 has excellent activity against **H1N1 influenza virus** .

HY-A0235

Antrafenine Stakane	Drug Derivative Influenza Virus	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Antrafenine (Stakane) is a derivative of 2-(quinolin-4-ylamino) benzoate, and is an orally active anti-inflammatory and analgesic agent. Antrafenine protects mammalian epithelial cells from cell death upon exposure to influenza A virus A/WSN/33 (H1N1). Antrafenine inhibits carrageenan-induced paw swelling in rats, and reduces exudate volume and total leukocyte infiltration in carrageenan- and calcium pyrophosphate dihydrate crystal-induced pleurisy in rats. Antrafenine can be used in studies related to influenza and pseudogout .

HY-143494

RSV/IAV-IN-3	RSV Influenza Virus	Infection
RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of *respiratory syncytial virus* (RSV)** and influenza A virus (IAV) with EC₅₀ values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC₅₀ values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC₅₀ of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage .

HY-13317R

Oseltamivir (Standard) GS 4104 (Standard)	Reference Standards Influenza Virus	Infection
Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-P990811

Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65))	Influenza Virus	Infection
Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is mouse-derived IgG2a κ type antibody inhibitor, targeting to influenza virus nucleoprotein. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) reacts with influenza virus nucleoprotein (NP). Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can induce passive immunity to influenza A virus. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can be used for the detections of western blot, flow cytometry and immunohistochemistry in Influenza A virus infection .

HY-10964R

Vadimezan (Standard) DMXAA (Standard); ASA-404 (Standard)	STING IFNAR Influenza Virus Reference Standards	Infection Cancer
Vadimezan (Standard) (DMXAA (Standard)) is the analytical standard of Vadimezan (HY-10964). This product is intended for research and analytical applications. Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

HY-131069A

MBX2329	Influenza Virus	Infection
MBX2329, a potent **influenza virus** inhibitor, specifically inhibits hemagglutinin (HA)-mediated viral entry with HIV/HA(H5) displaying IC₉₀ of 8.6 μM. MBX2329 inhibits a wide spectrum of influenza A viruses, which includes the 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, and oseltamivir-resistant A/H1N1 strains .

HY-N0224A

Goitrin (S)-Goitrin; L-5-Vinyl-2-thiooxazolidone	Influenza Virus	Metabolic Disease
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .

HY-177791

vRNPs degrader-1	PROTACs Influenza Virus	Infection
vRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research .

HY-N10843

4-O-Methylepisappanol	Influenza Virus	Infection
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-156786

TLD-1433	Reactive Oxygen Species (ROS) Influenza Virus SARS-CoV HSV	Infection
TLD-1433 is the fourth-generation ruthenium (II) based photodynamic compound (PDC). TLD-1433 is activated by green light (525 ± 25 nm) and efficiently generates ROS to achieve pathogen inactivation. After photoinactivation, TLD-1433 significantly induces lipid peroxidation of the cell membrane, which can directly damage the integrity of the viral envelope. TLD-1433 has ID₅₀ for enveloped viruses (such as *H1N1* influenza virus, coronavirus OC43, HSV-1, Zika virus) is as low as nanomolar level; for non-enveloped viruses (such as adenovirus Ad5, mammalian rotavirus MRV), a concentration of micro-molar level is required for inactivation. TLD-1433 has antigen retention property and can be used for the preparation of inactivated vaccines .

HY-116182

RO5487624	Influenza Virus	Infection
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus .

HY-129150

Ganoderic acid TR	Influenza Virus	Infection
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-N7915

Nepasaikosaponin K	Influenza Virus	Infection
Nepasaikosaponin K is an *anti-influenza* agent. Nepasaikosaponin K shows an EC₅₀ of 17.91 μM against influenza virus A/WSN/33 (H1N1) in 239T-Gluc cells .

HY-131059

CBS1117	Influenza Virus	Infection
CBS1117 is a virus entry inhibitor with an IC₅₀ of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1). CBS1117 interferes with the hemagglutinin (HA)-mediated fusion process .

HY-N16441

Pulvic acid	Endogenous Metabolite Influenza Virus	Infection
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-N16425

Mitorubrin (-)-Mitorubrin	Influenza Virus	Infection
Mitorubrin ((-)-Mitorubrin) is a compound that can be isolated from Penicillium purpurogenum JS03-21. Mitorubrin shows no significant inhibitory activity against the H1N1 influenza virus (IC₅₀ > 200 μM) .

HY-161902

MI-1904	Ser/Thr Protease Influenza Virus SARS-CoV	Infection
MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against **influenza virus** H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows *anti-influenza* virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-N17236

Forsyshiyanine A	β-glucuronidase Influenza Virus RSV	Infection
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of β-glucuronidase from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against **influenza A virus** (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-105395

BCX-1898	Influenza Virus	Infection
BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC₅₀s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model .

HY-N15215

Antiviral agent 64	Enterovirus Influenza Virus RSV HSV	Infection Cancer
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and **influenza virus H1N1, with EC₅₀** of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-100858

PP7	Influenza Virus	Infection
PP7 is a potent PB1-PB2 interaction inhibitor with an IC₅₀ of 8.6 μM, and their inhibition against viral polymerase activity (IC₅₀=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC₅₀=1.4 μM), A(H7N9) and A(H9N2) subtypes .

HY-N2264

Wulignan A1	Influenza Virus	Infection
Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus *H1N1* and *H1N1-TR* (a Tamiflu agent resistant virus strain) activities .

HY-N9019

1,4-Epidioxybisabola-2,10-dien-9-one	Influenza Virus	Infection
1,4-Epidioxybisabola-2,10-dien-9-one is a 1,4-epidioxy-bisabola-2,12-diene derivate, which can be isolated from Curcuma longa L. 1,4-Epidioxybisabola-2,10-dien-9-one exhibits antiviral activity against influenza virus A/PR/8/34 (H1N1) in the MDCK cell line with an IC₅₀ of 16.79 ± 4.03 μg/mL .

HY-162801

Neuraminidase-IN-21	Influenza Virus	Infection
Neuraminidase-IN-21 (Compound 6d) is an influenza H1N1 virus Neuraminidase inhibitor, with IC₅₀s of 0.30 µM for Neuraminidase, and 30.01 µM for H1N1 strain of influenza. Neuraminidase-IN-21 formsg three hydrogen bonds with Arg292, Arg371, and Tyr406 of Neuraminidase .

HY-P0313

CEF6	Influenza Virus	Infection
CEF6 is a 9-aa-long peptide corresponding to aa 418-426 of the influenza A virus (H1N1) nucleocapsid protein.

HY-N15217

Antiviral agent 65	Influenza Virus	Infection
Antiviral agent 65 (compound 9) is an antiviral agent that targets influenza *H1N1* virus (EC₅₀=7 μg/mL) .

HY-151967

Anti-IAV agent 1	Influenza Virus	Infection
Anti-IAV agent 1 (Compound (R)-1a) is an orally active anti-influenza *A virus* (IAV) agent with IC₅₀*s of 0.03 and 0.06 μM against IAV H1N1* and Oseltamivir-resistant IAV H1N1 strains, respectively .

HY-155476

Influenza virus-IN-8	Influenza Virus	Infection
Influenza virus-IN-8 (compound A4) is an inhibitor of influenza virus (Influenza Virus) that induces viral nucleoprotein (NP) aggregation and prevents its nuclear accumulation. Influenza virus-IN-8 has broad-spectrum anti-influenza activity and can inhibit the replication and transcription of influenza A virus. Influenza virus-IN-8 also inhibits Oseltamivir (HY-13317)-resistant H1N1/pdm09 strains .

HY-132286

2-PADQZ	Protein Arginine Deiminase	Infection
2-PADQZ is an antiviral compound with activity against influenza viruses. 2-PADQZ specifically binds to the influenza A virus RNA promoter and forms a binding site at the internal loop. 2-PADQZ has a significant inhibitory effect on H1N1 and H3N2 influenza A viruses and influenza B viruses .

HY-120690

RO5464466	Influenza Virus	Infection
RO5464466 is an hemagglutinin (HA) inhibitor of influenza *H1N1* viruses. RO5464466 inhibits HA-mediated hemolysis of chicken erythrocytes with the IC₅₀ of 0.29 μM .

HY-155110

Antiviral agent 34	DNA/RNA Synthesis Influenza Virus	Infection
Antiviral agent 34 is a potent and orally active antiviral agent against *influenza* A and B subtypes with an EC₅₀ value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research .

HY-175808

VF-57a	Influenza Virus	Infection
VF-57a (Compound 23) is an Influenza A virus (IAV) fusion inhibitor. VF-57 has potent antiviral activities against authentic A/H1N1 virus with EC₅₀s of 0.92 and 0.31 μM for the A/H1N1 PR8 and A/H1N1 Virg09 strains, respectively. VF-57 significantly inhibits HA-mediated cell entry of A/H1N1- and A/H5N1-pseudoviruses, prevents the HA refolding at pH 5.2. VF-57a can be used for IAV infections research .

HY-N10605

Maniwamycin E	SARS-CoV Influenza Virus	Infection
Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .

HY-163659

Anti-Influenza agent 6	Influenza Virus	Infection
Anti-Influenza agent 6 (compound 19b) shows inhibitory activity against A/WSN/33/H1N1 (EC₅₀ = 0.015 μM) and influenza B virus Yamagata/16/88 (EC₅₀ = 0.073 μM) and Victotis/2/87 (EC₅₀ = 0.067 μM) .

HY-157249

Antiviral agent 43	Influenza Virus	Infection
Antiviral agent 43 (compound 16) is a potent and orally active **influenza A viruses** entry inhibitor. Antiviral agent 43 inhibits replications of influenza A strains VH04-H5N1 and PR8-H1N1 with EC₅₀s of 240 nM and 72 nM, respectively .

HY-162492

Influenza A virus-IN-14	Influenza Virus	Infection
Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC₅₀ of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC₅₀ of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse .

Cat. No.	Product Name	Target	Research Area