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Cat. No.: HY-162492

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Influenza A virus-IN-14

Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC₅₀ of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC₅₀ of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse.

For research use only. We do not sell to patients.

CAS No.: 3050773-93-5
Formula: C₂₂H₂₅F₃N₂O₄
Molecular Weight:438.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Influenza A virus-IN-14 Chemical Structure

CAS No.: 3050773-93-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

EC₅₀: 23 nM (H1N1)

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	CC₅₀	>100 μM Compound: 37	Cytotoxicity against human Calu-3 cells assessed as cell viability measured after 3 days by CellTiter-Lumi Steady Plus Luminescent Cell Viability Assay Kit Cytotoxicity against human Calu-3 cells assessed as cell viability measured after 3 days by CellTiter-Lumi Steady Plus Luminescent Cell Viability Assay Kit	[PMID: 38736187]

Chemical Information

CAS No. 3050773-93-5
Molecular Weight 438.44
Formula C₂₂H₂₅F₃N₂O₄
SMILES

CO/N=C(C1(CNC2=O)CCC1)\CCCOC(C(CC3=C2C=CC(C(F)(F)F)=C3)=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu D, et al., Modular Biomimetic Strategy Enables Discovery and SAR Exploration of Oxime Macrocycles as Influenza A Virus (H1N1) Inhibitors. J Med Chem. 2024 May 23;67(10):8201-8224. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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