3050773-93-5
Chemical Structure
Influenza A virus-IN-14
- CAS No.: 3050773-93-5
- Formula:C22H25F3N2O4
- Molecular Weight:438.44
InChIKey: WYKOLNXDZUSRAL-OVVQPSECSA-N
SMILES: CO/N=C(C1(CNC2=O)CCC1)\CCCOC(C(CC3=C2C=CC(C(F)(F)F)=C3)=C)=O
Biological Activity: Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC50 of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC50 of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse[1].
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Influenza A virus-IN-14 | Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC50 of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC50 of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse. | |||||||||||||||||||||
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