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製品番号: HY-162242

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Cap-dependent endonuclease-IN-27

Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase (EC₅₀ = 12.26 nM).

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CAS 番号: 2741952-21-4
分子式: C₂₃H₁₉F₂N₃O₄
分子量:439.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Cap-dependent endonuclease-IN-27 構造式

CAS 番号: 2741952-21-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	CC₅₀	13.3 μM Compound: 8	Cytotoxicity against human A-375 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human A-375 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
CCRF-CEM	CC₅₀	6.48 μM Compound: 8	Cytotoxicity against human CCRF-CEM cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human CCRF-CEM cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
COLO 205	CC₅₀	7.04 μM Compound: 8	Cytotoxicity against human COLO 205 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human COLO 205 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
H1-HeLa	CC₅₀	9.77 μM Compound: 8	Cytotoxicity against human H1-HeLa cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human H1-HeLa cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
HEK293	CC₅₀	20.3 μM Compound: 8	Cytotoxicity against HEK293 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against HEK293 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
HEp-2	CC₅₀	12.45 μM Compound: 8	Cytotoxicity against human HEp-2 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human HEp-2 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
HepG2	CC₅₀	5.19 μM Compound: 8	Cytotoxicity against human HepG2 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human HepG2 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
MOLT-4	CC₅₀	4.13 μM Compound: 8	Cytotoxicity against human MOLT-4 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human MOLT-4 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]
MRC5	CC₅₀	19.95 μM Compound: 8	Cytotoxicity against human MRC5 cells incubated for 3 days by CellTiter-Glo assay Cytotoxicity against human MRC5 cells incubated for 3 days by CellTiter-Glo assay	[PMID: 38301207]

化学情報

CAS 番号 2741952-21-4
分子量 439.41
分子式 C₂₃H₁₉F₂N₃O₄
SMILES

O=C1N(C)[C@@]2([H])N(N3C1=C(O)C(C=C3)=O)[C@H](C4=CC=CC=C4)C5=CC(F)=C(F)C=C5OCC2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Signal Pathway Related

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Feng J, et al. Discovery of a Macrocyclic Influenza Cap-Dependent Endonuclease Inhibitor. J Med Chem. 2024 Feb 22;67(4):2570-2583. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Cap-dependent endonuclease-IN-27

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化学情報
プロトコル
純度とドキュメンテーション
参考文献

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Cap-dependent endonuclease-IN-27

生物活性

製品説明

Cellular Effect

化学情報

プロトコル

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Cap-dependent endonuclease-IN-27 関連分類

HY-162242 関連分類

Bioz

Keywords

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