1. Anti-infection
  2. Influenza Virus
  3. ML303

ML303 

Cat. No.: HY-126136
Handling Instructions

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1.

For research use only. We do not sell to patients.

ML303 Chemical Structure

ML303 Chemical Structure

CAS No. : 1638211-04-7

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Description

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

IC50 & Target

EC50: 0.7 μM (H1N1)[1].

In Vitro

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1].

Western Blot Analysis[1]

Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours.
Concentration: 20 μM.
Incubation Time: 6 hours.
Result: Restored IFN-β mRNA levels in MDCK cells.
Molecular Weight

399.37

Formula

C₂₁H₁₆F₃N₃O₂

CAS No.

1638211-04-7

SMILES

OC1=CC=C(C2=CC=NC3=C2C(C)=NN3C4=CC=C(C(F)(F)F)C=C4)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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