1. Anti-infection
  2. Influenza Virus
  3. ML303

ML303 

Cat. No.: HY-126136 Purity: 99.62%
COA Handling Instructions

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1.

For research use only. We do not sell to patients.

ML303 Chemical Structure

ML303 Chemical Structure

CAS No. : 1638211-04-7

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1 mg USD 150 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

IC50 & Target

EC50: 0.7 μM (H1N1)[1].

In Vitro

ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours.
Concentration: 20 μM.
Incubation Time: 6 hours.
Result: Restored IFN-β mRNA levels in MDCK cells.
Molecular Weight

399.37

Formula

C21H16F3N3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C2=CC=NC3=C2C(C)=NN3C4=CC=C(C(F)(F)F)C=C4)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5039 mL 12.5197 mL 25.0394 mL
5 mM 0.5008 mL 2.5039 mL 5.0079 mL
10 mM 0.2504 mL 1.2520 mL 2.5039 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.62%

References
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ML303 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ML303
Cat. No.:
HY-126136
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