Neuraminidase-IN-10
Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2685786-29-0
- Formula: C26H34N2O5S
- Molecular Weight:486.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | CC50 |
>250 μM
Compound: 12e
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Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
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[PMID: 35939763] |
| MDCK | CC50 |
>250 μM
Compound: 12e
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Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35939763] |
Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC50 value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC50 values of 0.04 ± 0.04 and 28.70 ± 1.61 μM, respectively in MDCK Cells[1]. Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T1/2 (min), CLint(mic) (μL/min/kg), CLint (liver) (mL/min/kg) and remaining (T=60 min)(%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SPF Chicken Embryonated Egg[1]
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Dosage:0.156 mM; 0.625 mM; 2.5 mM; 10 mM
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Administration:Injected into the egg
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Result:were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of Neuraminidase-IN-10 (H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively) at 2.5 mM and 10 mM[1].
Chemical Information
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CAS No. 2685786-29-0
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Molecular Weight 486.62
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Formula C26H34N2O5S
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SMILES
O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NCC2=CC=C(C3=CC=CS3)C=C2OC)C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuraminidase-IN-10 Related Classifications
HY-151103 Related Classifications
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