Oseltamivir-d₅

Name: Oseltamivir-d 5
Brand: MedChemExpress
SKU: HY-13317S3
Rating: 4.5 (0 reviews)

Cat. No.: HY-13317S3: Data Sheet
COA

SDS
Handling Instructions
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Oseltamivir-d₅ is the deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀ of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent.

For research use only. We do not sell to patients.

Oseltamivir-d₅ Chemical Structure

CAS No. : 1093851-63-8

Size	Stock	Quantity
2 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Other Forms of Oseltamivir-d₅:

Oseltamivir In-stock
Oseltamivir-d₅ (hydrochloride) Get quote
Oseltamivir-d₅ phosphate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Oseltamivir-d₅ is the deuterium labeled Oseltamivir^[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀ of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

317.44

Formula

C₁₆H₂₃D₅N₂O₄

CAS No.

1093851-63-8

Unlabeled CAS

196618-13-0

Appearance

Solid

Color

White to off-white

SMILES

CCC(CC)O[C@H]1[C@@H]([C@H](CC(C(OC(C([2H])([2H])[2H])([2H])[2H])=O)=C1)N)NC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 104 mg/mL (327.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1502 mL	15.7510 mL	31.5020 mL
5 mM	0.6300 mL	3.1502 mL	6.3004 mL
10 mM	0.3150 mL	1.5751 mL	3.1502 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.49%

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Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (258 KB) MS (178 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1502 mL	15.7510 mL	31.5020 mL	78.7550 mL
	5 mM	0.6300 mL	3.1502 mL	6.3004 mL	15.7510 mL
	10 mM	0.3150 mL	1.5751 mL	3.1502 mL	7.8755 mL
	15 mM	0.2100 mL	1.0501 mL	2.1001 mL	5.2503 mL
	20 mM	0.1575 mL	0.7876 mL	1.5751 mL	3.9378 mL
	25 mM	0.1260 mL	0.6300 mL	1.2601 mL	3.1502 mL
	30 mM	0.1050 mL	0.5250 mL	1.0501 mL	2.6252 mL
	40 mM	0.0788 mL	0.3938 mL	0.7876 mL	1.9689 mL
	50 mM	0.0630 mL	0.3150 mL	0.6300 mL	1.5751 mL
	60 mM	0.0525 mL	0.2625 mL	0.5250 mL	1.3126 mL
	80 mM	0.0394 mL	0.1969 mL	0.3938 mL	0.9844 mL
	100 mM	0.0315 mL	0.1575 mL	0.3150 mL	0.7876 mL