1093851-63-8
1093851-63-8
Chemical Structure
Oseltamivir-d5
- CAS No.: 1093851-63-8
- Formula:C16H23D5N2O4
- Molecular Weight:317.44
IUPAC Name: ethyl-d5 (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
InChIKey: VSZGPKBBMSAYNT-VQUPXQQCSA-N
SMILES: CCC(CC)O[C@H]1[C@@H]([C@H](CC(C(OC(C([2H])([2H])[2H])([2H])[2H])=O)=C1)N)NC(C)=O
Biological Activity: Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].
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Oseltamivir-d5 | Oseltamivir-d5 is the deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent. | |||||||||||||||||||||
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Oseltamivir (Standard) | 99.90% | Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. | ||||||||||||||||||||
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Oseltamivir-d3 | 99.13% | Oseltamivir-d3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent. | ||||||||||||||||||||
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Oseltamivir-d3 hydrochloride | Oseltamivir-d3 hydrochloride is the deuterium-labeled Oseltamivir (HY-13317). Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent. | |||||||||||||||||||||
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Oseltamivir-d3-1 | Oseltamivir-d3-1 is the deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent. | |||||||||||||||||||||
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Oseltamivir-d5 (hydrochloride) | Oseltamivir-d5 (hydrochloride) is the deuterium labeled Oseltamivir hydrochloride. | |||||||||||||||||||||
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Oseltamivir | 99.94% | Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]
