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Cat. No.: HY-181785

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Influenza A virus-IN-18

Influenza A virus-IN-18 (Compound C2e) is an orally active inhibitor of Influenza A virus (IC₅₀: 2.5 μM against PR8/H1N1; 6.42 μM against H3N2). Influenza A virus-IN-18 binds directly to the H1N1/PR8 HA protein with high affinity, with a K_D of 0.25 μM. Influenza A virus-IN-18 is applicable to research related to Influenza A virus infection.

For research use only. We do not sell to patients.

CAS No.: 3085746-63-7
Formula: C₃₅H₄₀N₄O₇
Molecular Weight:628.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Influenza A virus-IN-18 Chemical Structure

CAS No.: 3085746-63-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Influenza A virus-IN-18 (1.25-20 μM) binds directly to H1N1/PR8 HA protein with high affinity, exhibiting a K_D of 0.25 μM^[1].
Influenza A virus-IN-18 (48 h) potently inhibits H1N1 virus replication in MDCK cells with an IC₅₀ of 2.5 μM and exhibits no cytotoxicity at concentrations up to 300 μM^[1].
Influenza A virus-IN-18 (48 h) inhibits H3N2 virus replication in MDCK cells with an IC₅₀ of 6.42 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	Bioavailability	MRT
Mice^[1]	2.0 mg/kg	i.v.	3610 ng/mL	/	1.09 h	/	1.6 h
Mice^[1]	10.0 mg/kg	p.o.	2711 ng/mL	0.5 h	2.13 h	9.5 %	/

In Vivo

Influenza A virus-IN-18 (C2e) (2.5-5 mg/kg/day; p.o.; once a day) achieves a survival rate over 50% in H1N1-infected BALB/c mice, with superior weight recovery compared to control treatments^[1].
Influenza A virus-IN-18 (1000 mg/kg; p.o.; single dose) is well tolerated in ICR mice, with no observed toxicity or organ pathology^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3085746-63-7
Molecular Weight 628.71
Formula C₃₅H₄₀N₄O₇
SMILES

OC1=C(C=C(C(O)=C1CC2=C(NC3=CC(NC(CN4CCN(CC4)C)=O)=CC=C32)CC5=C(C(C)=CC(C(C)=O)=C5O)O)C(C)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gai W, et al. Pocket-Based Generative Diffusion Model Accelerates Potent Influenza A Hemagglutinin Inhibitor Discovery. J Med Chem. 2026;69(4):4969-4983. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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