2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-19

Influenza A virus-IN-19 (Compound (S)-63) is an orally active, selective Influenza A virus inhibitor with an EC50 of 0.44 μM. Influenza A virus-IN-19 exhibits moderate binding affinity to Hemagglutinin, with a Kd of 5.66 μM. Influenza A virus-IN-19 inhibits trypsin-mediated cleavage of HA0, blocks the early viral entry process, and suppresses the replication of Influenza A virus. Influenza A virus-IN-19 improves the survival rate of mice in lethal influenza models. Influenza A virus-IN-19 can be used in studies related to Influenza A virus infection.

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Influenza A virus-IN-19

Influenza A virus-IN-19 Chemical Structure

CAS No. : 3027187-19-2

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Influenza A virus-IN-19 Related Antibodies

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Description

Influenza A virus-IN-19 (Compound (S)-63) is an orally active, selective Influenza A virus inhibitor with an EC50 of 0.44 μM. Influenza A virus-IN-19 exhibits moderate binding affinity to Hemagglutinin, with a Kd of 5.66 μM. Influenza A virus-IN-19 inhibits trypsin-mediated cleavage of HA0, blocks the early viral entry process, and suppresses the replication of Influenza A virus. Influenza A virus-IN-19 improves the survival rate of mice in lethal influenza models. Influenza A virus-IN-19 can be used in studies related to Influenza A virus infection[1].

In Vitro

Influenza A virus-IN-19 potently inhibits influenza A virus H1N1 (A/FM/1/47) in MDCK cells, with an EC50 of 0.44 μM and a selectivity index of 210.75[1].
Influenza A virus-IN-19 potently inhibits oseltamivir (HY-13317)-resistant influenza A virus H1N1 (A/Tianjin Jinnan/15/2009) in MDCK cells, with an EC50 of 0.23 μM and a selectivity index of 403.17; it also inhibits influenza A virus H3N2 (A/HanFang/359/95), with an EC50 of 12.11 μM and a selectivity index of 5.51[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-19 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Cmax AUC0-inf MRT0-inf Tmax F
Mice[1] 2 mg/kg i.v. 1.32 h 1257 ng/mL 520 ng·h/mL 0.76 h / /
Mice[1] 50 mg/kg p.o. 4.30 h 1389 ng/mL 5041 ng·h/mL 5.02 h 0.67 h 38.78 %
In Vivo

Influenza A virus-IN-19 (administered orally, once before infection followed by twice daily for 7 days at doses of 5-45 mg/kg) exerts protective effects on female KM mice against lethal influenza infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice (female, 13−15 g, intranasally infected with 3 LD50 of mouse-adapted influenza virus A/Puerto Rico/8/1934)[1]
Dosage: 5 mg/kg; 15 mg/kg; 45 mg/kg
Administration: p.o.; once pre-infection, then twice daily; 7 days
Result: Provided 0% survival at 5 mg/kg.
Achieved 20% survival at 15 mg/kg.
Resulted in 0% survival due to treatment-related toxicity at 45 mg/kg.
Caused progressive body weight loss across all treatment groups; surviving mice began to regain weight following treatment discontinuation.
Molecular Weight

390.26

Formula

C16H14Cl2FNO3S
CAS No.
SMILES

O=S(C1=C(C=C(C=C1)Cl)Cl)(N2CCO[C@H](C2)C3=C(C=CC=C3)F)=O
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Purity & Documentation
References
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Influenza A virus-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-193027187-19-2Influenza Virusviral entryoseltamivir-resistant H1N1 strainlethal influenza mouse modelshemagglutininM2 proteinHA0 cleavageMDCK cellsNS1 proteininfluenza A virusH3N2 (A/HanFang/359/95)Inhibitorinhibitorinhibit

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