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Cat. No.: HY-182895

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Influenza A virus-IN-19

Influenza A virus-IN-19 (Compound (S)-63) is an orally active, selective Influenza A virus inhibitor with an EC₅₀ of 0.44 μM. Influenza A virus-IN-19 exhibits moderate binding affinity to Hemagglutinin, with a K_d of 5.66 μM. Influenza A virus-IN-19 inhibits trypsin-mediated cleavage of HA0, blocks the early viral entry process, and suppresses the replication of Influenza A virus. Influenza A virus-IN-19 improves the survival rate of mice in lethal influenza models. Influenza A virus-IN-19 can be used in studies related to Influenza A virus infection.

For research use only. We do not sell to patients.

CAS No.: 3027187-19-2
Formula: C₁₆H₁₄Cl₂FNO₃S
Molecular Weight:390.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Influenza A virus-IN-19 Chemical Structure

CAS No.: 3027187-19-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Influenza A virus-IN-19 potently inhibits influenza A virus H1N1 (A/FM/1/47) in MDCK cells, with an EC₅₀ of 0.44 μM and a selectivity index of 210.75^[1].
Influenza A virus-IN-19 potently inhibits oseltamivir (HY-13317)-resistant influenza A virus H1N1 (A/Tianjin Jinnan/15/2009) in MDCK cells, with an EC₅₀ of 0.23 μM and a selectivity index of 403.17; it also inhibits influenza A virus H3N2 (A/HanFang/359/95), with an EC₅₀ of 12.11 μM and a selectivity index of 5.51^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-inf	MRT_0-inf	T_max	F
Mice^[1]	2 mg/kg	i.v.	1.32 h	1257 ng/mL	520 ng·h/mL	0.76 h	/	/
Mice^[1]	50 mg/kg	p.o.	4.30 h	1389 ng/mL	5041 ng·h/mL	5.02 h	0.67 h	38.78 %

In Vivo

Influenza A virus-IN-19 (administered orally, once before infection followed by twice daily for 7 days at doses of 5-45 mg/kg) exerts protective effects on female KM mice against lethal influenza infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KM mice (female, 13−15 g, intranasally infected with 3 LD₅₀ of mouse-adapted influenza virus A/Puerto Rico/8/1934)^[1]
Dosage:

5 mg/kg; 15 mg/kg; 45 mg/kg
Administration:

p.o.; once pre-infection, then twice daily; 7 days
Result:

Provided 0% survival at 5 mg/kg.
Achieved 20% survival at 15 mg/kg.
Resulted in 0% survival due to treatment-related toxicity at 45 mg/kg.
Caused progressive body weight loss across all treatment groups; surviving mice began to regain weight following treatment discontinuation.

Chemical Information

CAS No. 3027187-19-2
Molecular Weight 390.26
Formula C₁₆H₁₄Cl₂FNO₃S
SMILES

O=S(C1=C(C=C(C=C1)Cl)Cl)(N2CCO[C@H](C2)C3=C(C=CC=C3)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song H, et al. Discovery and Optimization of Benzenesulfonamides as Potent Influenza A Virus Hemagglutinin Inhibitors. J Med Chem. 2026;69(7):7732-7755. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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