3027187-19-2
Chemical Structure
Influenza A virus-IN-19
- CAS No.: 3027187-19-2
- Formula:C16H14Cl2FNO3S
- Molecular Weight:390.26
InChIKey: JWBKCUDVDBGXNR-OAHLLOKOSA-N
SMILES: O=S(C1=C(C=C(C=C1)Cl)Cl)(N2CCO[C@H](C2)C3=C(C=CC=C3)F)=O
Biological Activity: Influenza A virus-IN-19 (Compound (S)-63) is an orally active, selective Influenza A virus inhibitor with an EC50 of 0.44 μM. Influenza A virus-IN-19 exhibits moderate binding affinity to Hemagglutinin, with a Kd of 5.66 μM. Influenza A virus-IN-19 inhibits trypsin-mediated cleavage of HA0, blocks the early viral entry process, and suppresses the replication of Influenza A virus. Influenza A virus-IN-19 improves the survival rate of mice in lethal influenza models. Influenza A virus-IN-19 can be used in studies related to Influenza A virus infection[1].
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Influenza A virus-IN-19 | Influenza A virus-IN-19 (Compound (S)-63) is an orally active, selective Influenza A virus inhibitor with an EC50 of 0.44 μM. Influenza A virus-IN-19 exhibits moderate binding affinity to Hemagglutinin, with a Kd of 5.66 μM. Influenza A virus-IN-19 inhibits trypsin-mediated cleavage of HA0, blocks the early viral entry process, and suppresses the replication of Influenza A virus. Influenza A virus-IN-19 improves the survival rate of mice in lethal influenza models. Influenza A virus-IN-19 can be used in studies related to Influenza A virus infection. | |||||||||||||||||||||
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Keywords
