Influenza HA (518-526)
Based on 1 Customer Validation
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and H1N1 strains. Influenza HA (518-526) binds to the mouse MHC class I allele Kd to form a complex, which is then recognized by specific CD8+ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8+ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), influenza virus, and H5N1 influenza.
For research use only. We do not sell to patients.
- Purity: 98.28%
- CAS No.: 186302-15-8
- Formula: C42H69N9O15
- Molecular Weight:940.05
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Influenza HA (518-526) (3 hours) incorporation into the neuraminidase stalk of PR8 influenza virus reduces the enzyme's specific activity to 15% of wild-type levels in purified virus preparations[1].
Influenza HA (518-526) (0.001 multiplicity of infection; 0-48 hours post-infection) incorporation into the neuraminidase stalk of PR8 influenza virus does not alter the virus's in vitro growth kinetics in MDCK cells[1].
Influenza HA (518-526) (72 hours) incorporation into the neuraminidase stalk of PR8 influenza virus does not change the virus's plaque size in MDCK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 186302-15-8
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Appearance Solid
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Molecular Weight 940.05
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Formula C42H69N9O15
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Color White to off-white
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Sequence
Ile-Tyr-Ser-Thr-Val-Ala-Ser-Ser-Leu
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Sequence Shortening
IYSTVASSL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. De Baets S, et al. Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice. J Virol. 2013;87(6):3314-3323. [Content Brief]
[2]. Jiang J, et al. Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells. Mech Ageing Dev. 2010;131(9):580-583. [Content Brief]
[3]. Hoelscher MA, et al. Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet. 2006;367(9509):475-481. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Influenza HA (518-526) Related Classifications
HY-P1837 Related Classifications
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