VIS-410

Cat. No.: HY-P991059 Purity: 99%: Data Sheet
COA

SDS

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VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits influenza virus replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as H1N1, H3N2, H5N1, and H7N9 (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection.

For research use only. We do not sell to patients.

VIS-410 Chemical Structure

CAS No. : 2043950-09-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

influenza A virus hemagglutinin HA

In Vitro

VIS-410 potently inhibits replication of multiple influenza A virus strains (including H3N2 and H5N1) in MDCK cells, with IC₅₀ values ranging from 0.3-11 µg/mL, by blocking HA-mediated membrane fusion^[2].
VIS-410 exhibits an IC₅₀ of 1.5 μg/mL against Duck/MN/1525/81 H5N1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VIS-410 (50 mg/kg; single dose, double dose) confers significant survival benefit in DBA mice infected with lethal H7N9 influenza A virus, and combination with Oseltamivir (HY-13317) reduces lung viral load and cytokine responses^[2].
VIS-410 confers significant survival benefit in mice infected with H3N2 influenza A virus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Accession

C3W5S1

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

149.157 kDa

CAS No.

2043950-09-8

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[VIS-410]

Shipping

Shipping with dry ice.

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 99%

Select Batch:

Data Sheet (257 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (59 KB) SEC-HPLC (78 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Koszalka P, et al. Influenza antivirals currently in late-phase clinical trial. Influenza Other Respir Viruses. 2017;11(3):240-246. [Content Brief]

[2]. Zeng LY, et al. Investigational hemagglutinin-targeted influenza virus inhibitors. Expert Opin Investig Drugs. 2017;26(1):63-73.

VIS-410 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VIS-4102043950-09-8VIS410VIS 410Influenza VirusGroup 2 influenza virusesMDCK cellsDBA miceHA stem regionviral replicationGroup 1 influenza virusesinfluenza virus haemagglutinininfluenza A(H7N9) virusHA-mediated membrane fusionH3N2 virusInhibitorinhibitorinhibit

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