Nylidrin hydrochloride
Based on 1 Customer Validation
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects.
For research use only. We do not sell to patients.
- Purity: 98.66%
- CAS No.: 849-55-8
- Formula: C19H26ClNO2
- Molecular Weight:335.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.18 μM in Xenopus oocytes (NR1A/2B NMDA receptor)[3]
Nylidrin (4.5-120 μM; 10-35 min) hydrochloride induces dose-dependent and reversible increases in the amplitude of the electroretinogram (ERG) b-wave, decreases in the c-wave, and configurational changes in the optic nerve compound action potential, without affecting perfusate flow or retinal vessel diameter in isolated, arterially perfused cat eyes[2].
Nylidrin hydrochloride potently antagonizes NR1A/2B NMDA receptors (IC50 = 0.18 μM) in Xenopus oocytes[3].
Nylidrin hydrochloride exhibits EC₅₀ values of 7.2 μM against A/Puerto Rico/8/1934 (H1N1) and 12.1 μM against A/Hong Kong/8/1968 (H3N2), with a CC50 of 549.2 μM in MDCK cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PR8-infected MDCK cells
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Concentration:1 μM, 10 μM, 100 μM
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Incubation Time:
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Result:Reduced the levels of NP, HA, and M1 in a dose-dependent manner.
Nylidrin (10 mg/kg) hydrochloride completely prevents mortality (100% survival vs. 0% in virus-only group) and body weight loss in BALB/c mice infected with mouse-adapted influenza A virus (maPR8, H1N1)[4].
Nylidrin (200 mg/kg; p.o.; twice a day) hydrochloride does not improve mortality in maPR8-infected mice but moderates the slope of body weight loss and increases the mean survival time by 1.4 days compared with the virus-only group[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 849-55-8
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Appearance Solid
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Molecular Weight 335.87
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Formula C19H26ClNO2
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Color White to off-white
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SMILES
OC(C(NC(C)CCC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl
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Synonyms
Buphenine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 41 mg/mL (122.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (14.89 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Boiteau GM, et al. Nylidrin HCl: a beta-sympathetic stimulant in the management of haemorrhagic shock. Can Anaesth Soc J. 1966 May;13(3):252-62. [Content Brief]
[2]. Niemeyer G, et al. Effects of buphenine (nylidrin) on the perfused mammalian eye. Graefes Arch Clin Exp Ophthalmol. 1987;225(1):33-8. [Content Brief]
[3]. Whittemore ER, et al. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur J Pharmacol. 1997 Oct 22;337(2-3):197-208. [Content Brief]
[4]. Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12(5):581. [Content Brief]
[5]. A Khandwala, et al. Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). I. Effect on release of histamine in vitro from rat peritoneal mast cells, guinea pig lung slices and human basophils. International Archives of Allergy & Applied Immunology, 1983, 70 (4) [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.9773 mL | 14.8867 mL | 29.7734 mL | 74.4336 mL |
| 5 mM | 0.5955 mL | 2.9773 mL | 5.9547 mL | 14.8867 mL | |
| 10 mM | 0.2977 mL | 1.4887 mL | 2.9773 mL | 7.4434 mL | |
| DMSO | 15 mM | 0.1985 mL | 0.9924 mL | 1.9849 mL | 4.9622 mL |
| 20 mM | 0.1489 mL | 0.7443 mL | 1.4887 mL | 3.7217 mL | |
| 25 mM | 0.1191 mL | 0.5955 mL | 1.1909 mL | 2.9773 mL | |
| 30 mM | 0.0992 mL | 0.4962 mL | 0.9924 mL | 2.4811 mL | |
| 40 mM | 0.0744 mL | 0.3722 mL | 0.7443 mL | 1.8608 mL | |
| 50 mM | 0.0595 mL | 0.2977 mL | 0.5955 mL | 1.4887 mL | |
| 60 mM | 0.0496 mL | 0.2481 mL | 0.4962 mL | 1.2406 mL | |
| 80 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9304 mL | |
| 100 mM | 0.0298 mL | 0.1489 mL | 0.2977 mL | 0.7443 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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