80 Results for "

Anti-obesity activity

" in MedChemExpress (MCE) Product Catalog:
Products (80)

80 Results for "Anti-obesity activity" in MCE Product Catalog:

38
Chlorogenic acid
Chlorogenic acid
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38 Publications Verification
Cat. No.: HY-N0055
CAS No.: 327-97-9
Synonyms: 3-O-Caffeoylquinic acid; Heriguard; NSC-407296
Category:  

Caprifoliaceae Anti-aging Lonicera japonica Thunb. Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .
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20
Evodiamine
Evodiamine
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20 Cited Publications
Cat. No.: HY-N0114
CAS No.: 518-17-2
Synonyms: (+)-Evodiamine; d-Evodiamine
Category:  

Alkaloids Piperidine Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Others

Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
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15
Fucoxanthin
Fucoxanthin
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15 Cited Publications
Cat. No.: HY-N2302
CAS No.: 3351-86-8
Synonyms: all-trans-Fucoxanthin
Category:  

Natural Products Anti-aging Whitening Agent Marine natural products Metabolic Disease Plants Food Research other families Sunscreen Marine algae Pigments Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer

Target:  

Bacterial PPAR c-Myc NO Synthase Caspase ERK

Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities .
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12
Pterostilbene
Pterostilbene
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12 Cited Publications
Cat. No.: HY-N0828
CAS No.: 537-42-8
Category:  

other families Monophenols Stilbenes Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Autophagy

Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .
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7
Isoacteoside
Isoacteoside
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7 Cited Publications
Cat. No.: HY-N0022
CAS No.: 61303-13-7
Synonyms: Isoverbascoside
Category:  

Simple Phenylpropanols Cistanche deserticola Ma Metabolic Disease Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β

Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .
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7
Kaempferide
Kaempferide
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7 Cited Publications
Cat. No.: HY-15449
CAS No.: 491-54-3
Purity:  99.80%
Synonyms: Kaempferol 4'-O-methyl ether
Category:  

Infection Flavonols Flavonoids Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae

Target:  

Estrogen Receptor/ERR Autophagy Bacterial Influenza Virus Apoptosis PI3K Akt GSK-3 FOXO β-catenin

Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research .
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5
Alisol A
Alisol A
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5 Cited Publications
Cat. No.: HY-N0853
CAS No.: 19885-10-0
Category:  

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Alismataceae Disease Research Fields

Target:  

AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .
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3
Fucosterol
Fucosterol
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3 Cited Publications
Cat. No.: HY-N4103
CAS No.: 17605-67-3
Category:  

other families Marine natural products Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids

Target:  

PARP Endogenous Metabolite

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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3
Abietic acid
Abietic acid
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3 Cited Publications
Cat. No.: HY-N6871
CAS No.: 514-10-3
Category:  

Infection Colophony Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial IKK Ferroptosis

Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .
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2
Cinnamyl Alcohol
Cinnamyl Alcohol
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2 Cited Publications
Cat. No.: HY-Y0078
CAS No.: 104-54-1
Category:  

Simple Phenylpropanols Metabolic Disease Phenylpropanoids Plants Fagaceae Disease Research Fields Croton poilanei Gagnep.

Target:  

Environmental Pollutants AMPK ERK Potassium Channel Akt ROCK NO Synthase PPAR

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities .
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2
(-)-Cedrene
(-)-Cedrene
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2 Cited Publications
Cat. No.: HY-135190
CAS No.: 469-61-4
Purity:  ≥98.0%
Synonyms: α-cedrene
Category:  

Infection Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Metabolic Disease Plants Disease Research Fields

Target:  

Environmental Pollutants Bacterial

(-)-Cedrene (α-cedrene) is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC50 = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC50 = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .
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2
Pradigastat
Pradigastat
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2 Cited Publications
Cat. No.: HY-16278
CAS No.: 956136-95-1
Synonyms: LCQ-908
Target:  

Acyltransferase BCRP OAT

Research Areas:  

Infection Metabolic Disease

Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
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2
S-Methyl-L-cysteine
S-Methyl-L-cysteine
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2 Cited Publications
Cat. No.: HY-B2188
CAS No.: 1187-84-4
Synonyms: L-S-Methylcysteine
Category:  

other families Ketones, Aldehydes, Acids Plants

Target:  

Reactive Oxygen Species (ROS)

S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
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2
KY-226
KY-226
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2 Cited Publications
Cat. No.: HY-120327
CAS No.: 1621673-53-7
Purity:  98.42%
Target:  

Phosphatase

Research Areas:  

Neurological Disease Metabolic Disease

KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .
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1
(±)-Catechin
(±)-Catechin
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1 Cited Publications
Cat. No.: HY-B1890
CAS No.: 7295-85-4
Synonyms: rel-Cianidanol; rel-Catechuic acid
Category:  

Cardiovascular Disease Neurological Disease Plants Camellia sinensis (L.) O. Ktze. Infection Phenols Polyphenols Disease Research Fields Inflammation/Immunology Theaceae

Target:  

COX

(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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1
Cetilistat
Cetilistat
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1 Cited Publications
Cat. No.: HY-14471
CAS No.: 282526-98-1
Purity:  ≥98.0%
Synonyms: ATL-962
Target:  

Lipase

Research Areas:  

Metabolic Disease

Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively .
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1
Allitol
Allitol
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1 Cited Publications
Cat. No.: HY-N2840
CAS No.: 488-44-8
Synonyms: Allodulcitol
Category:  

Natural Products Microorganisms Metabolic Disease Disease Research Fields Sweeteners Food Research

Target:  

Others

Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .
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1
Orobol
Orobol
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1 Cited Publications
Cat. No.: HY-N3127
CAS No.: 480-23-9
Category:  

Flavonoids Leguminosae Glycine max (L.) merr Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Isoflavones

Target:  

Casein Kinase PI3K VEGFR

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ) .
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1
Soyasaponin Ab
Soyasaponin Ab
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1 Cited Publications
Cat. No.: HY-N3026
CAS No.: 118194-13-1
Category:  

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields

Target:  

PPAR Apoptosis Reactive Oxygen Species (ROS)

Soyasaponin Ab is an orally active soyasaponin. Soyasaponin Ab inhibits PPARγ transcriptional activity. Soyasaponin Ab induces apoptosis in high concentrations. Soyasaponin Ab exerts anti-obesity, anti-oxidation, anti-inflammation, anti-aging effects. Soyasaponin Ab prevents Scopolamine (HY-N0296)-induced memory impairment .
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1
Mifobate
Mifobate
0 Images
1 Cited Publications
Cat. No.: HY-100277
CAS No.: 76541-72-5
Purity:  99.10%
Synonyms: SR-202
Target:  

PPAR

Research Areas:  

Metabolic Disease

Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects .
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