1. Cell Cycle/DNA Damage
  2. PPAR
  3. Mifobate

Mifobate (Synonyms: SR-202)

Cat. No.: HY-100277 Purity: >99.0%
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Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.

For research use only. We do not sell to patients.

Mifobate Chemical Structure

Mifobate Chemical Structure

CAS No. : 76541-72-5

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10 mM * 1 mL in DMSO USD 276 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].

IC50 & Target[1]

PPARγ

140 μM (IC50)

In Vitro

Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days[1].
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX)[1].

In Vivo

Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice[1]

Animal Model: Eight-week-old male ob/ob mice[1]
Dosage: 400 mg/kg
Administration: Feed (food admixture maintained for 20 days)
Result: Prevented the time-dependent increase in glucose concentrations.
Molecular Weight

358.65

Formula

C₁₁H₁₇ClO₇P₂

CAS No.

76541-72-5

SMILES

O=P(OC)(OC)OC(C1=CC=C(Cl)C=C1)P(OC)(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

MifobateSR-202SR202SR 202PPARPeroxisome proliferator-activated receptorstranscriptionalactivityadipocytedifferentiationstimulationselectiveantiobesityantidiabeticobesitytype 2diabetesInhibitorinhibitorinhibit

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Mifobate
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HY-100277
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