1. Cell Cycle/DNA Damage
  2. PPAR
  3. Mifobate

Mifobate (Synonyms: SR-202)

Cat. No.: HY-100277 Purity: 99.77%
Handling Instructions

Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.

For research use only. We do not sell to patients.

Mifobate Chemical Structure

Mifobate Chemical Structure

CAS No. : 76541-72-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 276 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 276 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Mifobate

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Description

Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].

IC50 & Target[1]

PPARγ

140 μM (IC50)

In Vitro

Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days[1].
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male ob/ob mice[1]
Dosage: 400 mg/kg
Administration: Feed (food admixture maintained for 20 days)
Result: Prevented the time-dependent increase in glucose concentrations.
Molecular Weight

358.65

Formula

C₁₁H₁₇ClO₇P₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (278.82 mM; Need ultrasonic)

H2O : 35.87 mg/mL (100.01 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7882 mL 13.9412 mL 27.8823 mL
5 mM 0.5576 mL 2.7882 mL 5.5765 mL
10 mM 0.2788 mL 1.3941 mL 2.7882 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.77%

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Product Name:
Mifobate
Cat. No.:
HY-100277
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