76541-72-5
Chemical Structure
Mifobate
Synonym(s): SR-202
- CAS No.: 76541-72-5
- Formula:C11H17ClO7P2
- Molecular Weight:358.65
IUPAC Name: (4-chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate
InChIKey: VQHUQHAPWMNBLP-UHFFFAOYSA-N
SMILES: O=P(OC)(OC)OC(C1=CC=C(Cl)C=C1)P(OC)(OC)=O
Biological Activity: Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].
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Mifobate | 99.85% | Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects. | ||||||||||||||||||||
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Mifobate (Standard) | ≥98% | Mifobate (Standard) is the analytical standard of Mifobate. This product is intended for research and analytical applications. Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects. | ||||||||||||||||||||
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