Hericenone D

Cat. No.: HY-N15385 Purity: 98.20%: Data Sheet
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Hericenone D, an orally active pancreatic lipase inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity.

For research use only. We do not sell to patients.

Hericenone D Chemical Structure

CAS No. : 137592-04-2

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5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Description

In Vitro

Hericenone D (3-100 μM; 24 h) does not exhibit significant neuroprotective activity against Tunicamycin (HY-A0098) or Thapsigargin (HY-13433)-induced ER stress-dependent cell death in murine neuroblastoma Neuro2a cells^[1].
Hericenone D (400 μg/mL; 30 min) exhibits significant pancreatic lipase inhibitory activity in a cell-free biochemical assay at a concentration of 400 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	murine neuroblastoma Neuro2a cells
Concentration:	3 μM; 10 μM; 30 μM
Incubation Time:	24 h
Result:	Did not exhibit significant neuroprotective activity against Tunicamycin or Thapsigargin-induced ER stress-dependent cell death.

In Vivo

Hericenone D (~0.09 g/day; p.o.; 14 days) reduces white adipose tissue in the visceral and subcutaneous fat, decreases fat tissue around the uterus and the kidney and decreases the levels of total cholesterol and leptin in the plasma parameters of female C57BL/6JJcl mice^[2].
Hericenone D (p.o.; 42 days) significantly reduces visceral and subcutaneous fat, decreases adipose tissue, increases lipid excreted from feces in female C57BL/6JJcl mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6JJcl mice (female; 12 weeks old)^[1]
Dosage:	~0.09 g/day
Administration:	p.o.; 14 days
Result:	Significantly reduced white adipose tissue in the visceral and subcutaneous fat. Decreased fat tissue around the uterus and the kidney. Significantly decreased the levels of total cholesterol and leptin in the plasma parameters.

Molecular Weight

598.85

Formula

C₃₇H₅₈O₆

CAS No.

137592-04-2

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCC(OCC1=C(C(O)=C(C(OC)=C1)C/C=C(C)/CC(/C=C(C)\C)=O)C=O)=O

Structure Classification

Initial Source

Microorganisms

Hericium erinaceus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 98.20%

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Data Sheet (277 KB) SDS (252 KB)

COA (239 KB) HNMR (129 KB) CNMR (128 KB) RP-HPLC (103 KB) MS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Kobayashi S, et al. Total Synthesis, Structure Revision, and Neuroprotective Effect of Hericenones C-H and Their Derivatives. J Org Chem. 2021;86(3):2602-2620. [Content Brief]

[2]. Hiraki E, et al. Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds. J Nat Med. 2017;71(3):482-491. [Content Brief]

Hericenone D Related Classifications

Metabolic Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hericenone D137592-04-2Lipaseendoplasmic reticulum stressneuroblastoma cellstunicamycinmurine neuroblastoma Neuro2a cellsmenopausal obesityanti-obesity activitynerve growth factorHericium erinaceuslipid absorptionpancreatic lipaseInhibitorinhibitorinhibit

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