2. Others
  3. Others
  4. JBSNF-000028 free base

JBSNF-000028 is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 µM, 0.19 µM and 0.21 µM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 can be used for the research of metabolic disorders.

For research use only. We do not sell to patients.

JBSNF-000028 free base Chemical Structure

JBSNF-000028 free base Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of JBSNF-000028 free base:

Other Forms of JBSNF-000028 free base:

JBSNF-000028 free base Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JBSNF-000028 is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 µM, 0.19 µM and 0.21 µM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 can be used for the research of metabolic disorders[1].

IC50 & Target

IC50: 0.033 µM (hNNMT), 0.19 µM (mkNNMT), 0.21 µM (mNNMT)[1]
In Vitro

JBSNF-000028 (24 h) inhibits NNMT activity with an EC50 of 2.5 µM in U2OS cells[1].
JBSNF-000028 (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 is inactive against a broad panel of targets related to metabolism and safety[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JBSNF-000028 free base Related Antibodies
In Vivo

JBSNF-000028 (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL6/N mice, diet induced obesity (DIO) model[1]
Dosage: 50 mg/kg
Administration: Oral administration, b.i.d for 27 days
Result: Significantly reduced the body weight and fed blood glucose. Reduced 1-methyl-nicotinamide (MNA) levels in visceral WAT and liver. Led to a statistically significant reduction in plasma triglyceride, plasma LDL cholesterol, liver triglyceride and liver total cholesterol.
Animal Model: Male C57BL6/N mice[1]
Dosage: 1 mg/kg and 10 mg/kg
Administration: Intravenous and oral administration (Pharmacokinetic Analysis)
Result: Pharmacokinetic parameters of JBSNF-0000028 in mice following intravenous (1 mg/kg) and oral administration (10 mg/kg)[1].
PK parameters Intravenous Oral
Dose (mg/kg) 1 10
AUC0–t (ng h/mL) 446 1369
C0/Cmax (ng/mL) 432 452
Tmax (h) - 1.00
T1/2 (h) 1.77 2.36
Tlast (h) 8.00 10.0
Cl (mL/min/kg) 36.6 -
Vd (L/kg) 8.69 -
F (%) - 30
Molecular Weight

187.24

Formula

C11H13N3
SMILES

CN1CC2=C3C(CCN3C1=N)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JBSNF-000028 free base Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Otherstype 2 diabetesliver diseasesnicotinamide N-methyltransferaseNNMTInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JBSNF-000028 free base
Cat. No.:
HY-151500
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.