3026599-90-3
Chemical Structure
JBSNF-000028 free base
- CAS No.: 3026599-90-3
- Formula:C11H13N3
- Molecular Weight:187.24
IUPAC Name: 1-azido-4-bromobutane
InChIKey: QHQIGFVXRSNTKN-UHFFFAOYSA-N
SMILES: CN1CC2=C3C(CCN3C1=N)=CC=C2
Biological Activity:
JBSNF-00002 free base is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 free base can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 free base exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 free base can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JBSNF-000028 free base | 98.03% | JBSNF-00002 free base is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 free base can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 free base exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 free base can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease. |
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