BRD4 Inhibitor-12

Cat. No.: HY-132128 Purity: 99.34%: Data Sheet
COA

SDS
Handling Instructions
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BRD4 Inhibitor-12 (Compound 9) is a BRD4 ligand, and can be used for research of cancer, infammation.

For research use only. We do not sell to patients.

BRD4 Inhibitor-12 Chemical Structure

CAS No. : 328956-24-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Epigenetic Reader Domain Isoform Specific Products:

View All Isoforms

Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

Biological Activity
Purity & Documentation
References
Customer Review

Description

BRD4 Inhibitor-12 (Compound 9) is a BRD4 ligand, and can be used for research of cancer, infammation^[1].

IC₅₀ & Target^[1]

BRD4

Molecular Weight

241.08

Formula

C₉H₉BrN₂O

CAS No.

328956-24-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC2=C(C=C(Br)C=C2)CN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (207.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1480 mL	20.7400 mL	41.4800 mL
5 mM	0.8296 mL	4.1480 mL	8.2960 mL
10 mM	0.4148 mL	2.0740 mL	4.1480 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (269 KB) SDS (394 KB)

COA (248 KB) HNMR (241 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Wright DW, et al. Application of ESMACS binding free energy protocols to diverse datasets: Bromodomain-containing protein 4. Sci Rep. 2019 Apr 12;9(1):6017. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1480 mL	20.7400 mL	41.4800 mL	103.7000 mL
	5 mM	0.8296 mL	4.1480 mL	8.2960 mL	20.7400 mL
	10 mM	0.4148 mL	2.0740 mL	4.1480 mL	10.3700 mL
	15 mM	0.2765 mL	1.3827 mL	2.7653 mL	6.9133 mL
	20 mM	0.2074 mL	1.0370 mL	2.0740 mL	5.1850 mL
	25 mM	0.1659 mL	0.8296 mL	1.6592 mL	4.1480 mL
	30 mM	0.1383 mL	0.6913 mL	1.3827 mL	3.4567 mL
	40 mM	0.1037 mL	0.5185 mL	1.0370 mL	2.5925 mL
	50 mM	0.0830 mL	0.4148 mL	0.8296 mL	2.0740 mL
	60 mM	0.0691 mL	0.3457 mL	0.6913 mL	1.7283 mL
	80 mM	0.0519 mL	0.2593 mL	0.5185 mL	1.2963 mL
	100 mM	0.0415 mL	0.2074 mL	0.4148 mL	1.0370 mL