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  4. JBSNF-000028 hydrochloride

JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders.

For research use only. We do not sell to patients.

JBSNF-000028 hydrochloride Chemical Structure

JBSNF-000028 hydrochloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of JBSNF-000028 hydrochloride:

JBSNF-000028 hydrochloride Related Antibodies

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Description

JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders[1].

IC50 & Target

IC50: 0.033 μM (hNNMT), 0.19 μM (mkNNMT), 0.21 μM (mNNMT)[1]
In Vitro

JBSNF-000028 hydrochloride (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 hydrochloride (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 hydrochloride binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 hydrochloride is inactive against a broad panel of targets related to metabolism and safety[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JBSNF-000028 hydrochloride Related Antibodies
In Vivo

JBSNF-000028 hydrochloride (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 hydrochloride (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

223.70

Formula

C11H14ClN3
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN1CC2=C3C(CCN3C1=N)=CC=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (74.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4703 mL 22.3514 mL 44.7027 mL
5 mM 0.8941 mL 4.4703 mL 8.9405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4703 mL 22.3514 mL 44.7027 mL 111.7568 mL
5 mM 0.8941 mL 4.4703 mL 8.9405 mL 22.3514 mL
10 mM 0.4470 mL 2.2351 mL 4.4703 mL 11.1757 mL
15 mM 0.2980 mL 1.4901 mL 2.9802 mL 7.4505 mL
20 mM 0.2235 mL 1.1176 mL 2.2351 mL 5.5878 mL
25 mM 0.1788 mL 0.8941 mL 1.7881 mL 4.4703 mL
30 mM 0.1490 mL 0.7450 mL 1.4901 mL 3.7252 mL
40 mM 0.1118 mL 0.5588 mL 1.1176 mL 2.7939 mL
50 mM 0.0894 mL 0.4470 mL 0.8941 mL 2.2351 mL
60 mM 0.0745 mL 0.3725 mL 0.7450 mL 1.8626 mL
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JBSNF-000028 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Otherstype 2 diabetesliver diseasesnicotinamide N-methyltransferaseNNMTInhibitorinhibitorinhibit

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