JBSNF-000028 hydrochloride
Based on 1 Customer Validation
JBSNF-00002 hydrochloride is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 hydrochloride can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 hydrochloride exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 hydrochloride can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.
For research use only. We do not sell to patients.
- Purity: 95.64%
- Formula: C11H14ClN3
- Molecular Weight:223.70
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Anti-diabetic Compound Library
HY-L040
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Anti-Obesity Compound Library
HY-L087
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
IC50: 0.033 μM (hNNMT), 0.19 μM (mkNNMT), 0.21 μM (mNNMT)[1]
JBSNF-000028 hydrochloride (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 hydrochloride (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 hydrochloride binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 hydrochloride is inactive against a broad panel of targets related to metabolism and safety[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
JBSNF-000028 hydrochloride (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 223.70
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Formula C11H14ClN3
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Color Off-white to light yellow
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SMILES
CN1CC2=C3C(CCN3C1=N)=CC=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 16.67 mg/mL (74.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4703 mL | 22.3514 mL | 44.7027 mL | 111.7568 mL |
| 5 mM | 0.8941 mL | 4.4703 mL | 8.9405 mL | 22.3514 mL | |
| 10 mM | 0.4470 mL | 2.2351 mL | 4.4703 mL | 11.1757 mL | |
| 15 mM | 0.2980 mL | 1.4901 mL | 2.9802 mL | 7.4505 mL | |
| 20 mM | 0.2235 mL | 1.1176 mL | 2.2351 mL | 5.5878 mL | |
| 25 mM | 0.1788 mL | 0.8941 mL | 1.7881 mL | 4.4703 mL | |
| 30 mM | 0.1490 mL | 0.7450 mL | 1.4901 mL | 3.7252 mL | |
| 40 mM | 0.1118 mL | 0.5588 mL | 1.1176 mL | 2.7939 mL | |
| 50 mM | 0.0894 mL | 0.4470 mL | 0.8941 mL | 2.2351 mL | |
| 60 mM | 0.0745 mL | 0.3725 mL | 0.7450 mL | 1.8626 mL |
JBSNF-000028 hydrochloride Related Classifications
HY-151500B Related Classifications
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