Cinnamyl Alcohol

Name: Cinnamyl Alcohol
Brand: MedChemExpress
SKU: HY-Y0078
Rating: 5.0 (2 reviews)

Cat. No.: HY-Y0078 Purity: 98.58%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.

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Cinnamyl Alcohol 화학구조

CAS No. : 104-54-1

사이즈	재고	수량
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid or liquid
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
250 g	해외재고보유	Estimated Time of Arrival: December 31
500 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of Cinnamyl Alcohol:

2 Publications Citing Use of MCE Cinnamyl Alcohol

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All ROCK Isoform Specific Products:

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ROCK ROCK1 ROCK2

View All Akt Isoform Specific Products:

View All Isoforms

Akt Akt1 Akt2 Akt3

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

View All AMPK Isoform Specific Products:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities^[1].

In Vitro

Cinnamyl Alcohol (0.5-1 µg/µL, 24 h) inhibits LPS (HY-D1056) and IFN-γ-induced NO production in cell RAW264.7 through inhibition of iNOS^[4].
Cinnamyl Alcohol (0.4-2 mM, 24 h) activates K+ channels via the NO-cGMP-PKG pathway, inhibits Rho kinase, and attenuates Phenylephrine (HY-B0769)-induced vasoconstriction in rat thoracic aorta endothelial cells^[3].
Cinnamyl Alcohol (25 µM, 24-48 h) downregulates the expressions of adipogenesis-related proteins PPARγ, C/EBPα, FABP4 and adipogenesis-related proteins C/EBPβ, C/EBPδ, cyclin B1/D1/E1, and CDK2/6, arrests cell cycle at G0/G1 phase in 3T3-L1 cells, and inhibits the lipid accumulation^[2].
Cinnamyl Alcohol (25 µM, 60 min) activates the AMPKα phosphorylation, inhibits AKT and ERK1/2 signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	3T3-L1
Concentration:	25 µM
Incubation Time:	16-20 h
Result:	Downregulated expressions of PPARγ, C/EBPα, FABP4, C/EBPβ, C/EBPδ, cyclin B1/D1/E1, CDK2/6.

Cell Cycle Analysis^[2]

Cell Line:	3T3-L1
Concentration:	25 µM
Incubation Time:	24-48 h
Result:	Arrested cell cycle at G0/G1 phase.

Western Blot Analysis^[4]

Cell Line:	RAW246.7
Concentration:	0.5-1 µg/µL
Incubation Time:	24 h
Result:	Inhibited expression of iNOS.

In Vivo

Cinnamyl Alcohol (2 g/kg, po, single dose) exhibits anti-inflammatory activity in E. coli-induced sepsis mouse model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse E. coli-induced sepsis model^[5]
Dosage:	2 g/kg
Administration:	po, single dose
Result:	Reduced the inflammatory reaction in the liver, heart, lungs, and kidneys

분자량

134.18

화학식

C₉H₁₀O

CAS No.

104-54-1

Appearance

<30°C Solid,>33°C Liquid

Color

White to light yellow

SMILES

OC/C=C/C1=CC=CC=C1

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 200 mg/mL (1490.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (745.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4527 mL	37.2634 mL	74.5268 mL
5 mM	1.4905 mL	7.4527 mL	14.9054 mL
10 mM	0.7453 mL	3.7263 mL	7.4527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.34%

Select Batch:

Data Sheet (277 KB) SDS (796 KB)

COA (244 KB) HNMR (131 KB) GC (205 KB)

Handling Instructions (2659 KB)

References

[1]. Hwang DI, et al. Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors. Am J Chin Med. 2017;45(4):833-846. [Content Brief]

[2]. Choi YR, et al., Cinnamyl Alcohol Attenuates Adipogenesis in 3T3-L1 Cells by Arresting the Cell Cycle. Int J Mol Sci. 2024 Jan 5;25(2):693. [Content Brief]

[3]. Kang YH, et al., Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase. Exp Mol Med. 2012 Dec 31;44(12):749-55. [Content Brief]

[4]. Lee H S. Chemical composition of Cinnamomum cassia leaf oils and suppression effect of cinnamyl alcohol on nitric oxide synthase[J]. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 480-485.

[5]. Zou L, et al., The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway. Ann Transl Med. 2022 Jan;10(2):48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	7.4527 mL	37.2634 mL	74.5268 mL	186.3169 mL
	5 mM	1.4905 mL	7.4527 mL	14.9054 mL	37.2634 mL
	10 mM	0.7453 mL	3.7263 mL	7.4527 mL	18.6317 mL
	15 mM	0.4968 mL	2.4842 mL	4.9685 mL	12.4211 mL
	20 mM	0.3726 mL	1.8632 mL	3.7263 mL	9.3158 mL
	25 mM	0.2981 mL	1.4905 mL	2.9811 mL	7.4527 mL
	30 mM	0.2484 mL	1.2421 mL	2.4842 mL	6.2106 mL
	40 mM	0.1863 mL	0.9316 mL	1.8632 mL	4.6579 mL
	50 mM	0.1491 mL	0.7453 mL	1.4905 mL	3.7263 mL
	60 mM	0.1242 mL	0.6211 mL	1.2421 mL	3.1053 mL
	80 mM	0.0932 mL	0.4658 mL	0.9316 mL	2.3290 mL
	100 mM	0.0745 mL	0.3726 mL	0.7453 mL	1.8632 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.