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  5. Cinnamyl Alcohol

Cinnamyl Alcohol  (Synonyms: シンナミルアルコール)

製品番号: HY-Y0078 純度: 98.58%
COA 取扱説明書 Technical Support

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.

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Cinnamyl Alcohol

Cinnamyl Alcohol 構造式

CAS 番号 : 104-54-1

容量 価格（税別） 在庫状況 数量
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid or liquid
1 g $25 在庫あり
5 g $30 在庫あり
10 g $33 在庫あり
25 g $39 在庫あり
50 g $45 在庫あり
100 g $55 在庫あり
250 g $70 在庫あり
500 g $85 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Other Forms of Cinnamyl Alcohol:

Cinnamyl Alcohol 関連抗体

Top Publications Citing Use of Products

ROCK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ROCK ROCK1 ROCK2

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Akt Akt1 Akt2 Akt3

PPAR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PPARα PPARβ/δ PPARγ PPAR PPARδ

NO Synthase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
nNOS iNOS eNOS

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ERK ERK1 ERK2 ERK5 ERK8

AMPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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製品説明

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities[1].

体外実験

Cinnamyl Alcohol (0.5-1 µg/µL, 24 h) inhibits LPS (HY-D1056) and IFN-γ-induced NO production in cell RAW264.7 through inhibition of iNOS[4].
Cinnamyl Alcohol (0.4-2 mM, 24 h) activates K+ channels via the NO-cGMP-PKG pathway, inhibits Rho kinase, and attenuates Phenylephrine (HY-B0769)-induced vasoconstriction in rat thoracic aorta endothelial cells[3].
Cinnamyl Alcohol (25 µM, 24-48 h) downregulates the expressions of adipogenesis-related proteins PPARγ, C/EBPα, FABP4 and adipogenesis-related proteins C/EBPβ, C/EBPδ, cyclin B1/D1/E1, and CDK2/6, arrests cell cycle at G0/G1 phase in 3T3-L1 cells, and inhibits the lipid accumulation[2].
Cinnamyl Alcohol (25 µM, 60 min) activates the AMPKα phosphorylation, inhibits AKT and ERK1/2 signaling pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamyl Alcohol 関連抗体

Western Blot Analysis[2]

Cell Line: 3T3-L1
Concentration: 25 µM
Incubation Time: 16-20 h
Result: Downregulated expressions of PPARγ, C/EBPα, FABP4, C/EBPβ, C/EBPδ, cyclin B1/D1/E1, CDK2/6.

Cell Cycle Analysis[2]

Cell Line: 3T3-L1
Concentration: 25 µM
Incubation Time: 24-48 h
Result: Arrested cell cycle at G0/G1 phase.

Western Blot Analysis[4]

Cell Line: RAW246.7
Concentration: 0.5-1 µg/µL
Incubation Time: 24 h
Result: Inhibited expression of iNOS.
体内実験

Cinnamyl Alcohol (2 g/kg, po, single dose) exhibits anti-inflammatory activity in E. coli-induced sepsis mouse model[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse E. coli-induced sepsis model[5]
Dosage: 2 g/kg
Administration: po, single dose
Result: Reduced the inflammatory reaction in the liver, heart, lungs, and kidneys
分子量

134.18

分子式

C9H10O
CAS 番号
Appearance

<30°C Solid,>33°C Liquid

Color

White to light yellow

SMILES

OC/C=C/C1=CC=CC=C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (1490.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (745.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4527 mL 37.2634 mL 74.5268 mL
5 mM 1.4905 mL 7.4527 mL 14.9054 mL
10 mM 0.7453 mL 3.7263 mL 7.4527 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.34%

COA (244 KB) HNMR (131 KB) GC (205 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 7.4527 mL 37.2634 mL 74.5268 mL 186.3169 mL
5 mM 1.4905 mL 7.4527 mL 14.9054 mL 37.2634 mL
10 mM 0.7453 mL 3.7263 mL 7.4527 mL 18.6317 mL
15 mM 0.4968 mL 2.4842 mL 4.9685 mL 12.4211 mL
20 mM 0.3726 mL 1.8632 mL 3.7263 mL 9.3158 mL
25 mM 0.2981 mL 1.4905 mL 2.9811 mL 7.4527 mL
30 mM 0.2484 mL 1.2421 mL 2.4842 mL 6.2106 mL
40 mM 0.1863 mL 0.9316 mL 1.8632 mL 4.6579 mL
50 mM 0.1491 mL 0.7453 mL 1.4905 mL 3.7263 mL
60 mM 0.1242 mL 0.6211 mL 1.2421 mL 3.1053 mL
80 mM 0.0932 mL 0.4658 mL 0.9316 mL 2.3290 mL
100 mM 0.0745 mL 0.3726 mL 0.7453 mL 1.8632 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cinnamyl Alcohol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinnamyl Alcohol104-54-1ROCKAktPPARPotassium ChannelEnvironmental PollutantsNO SynthaseERKAMPKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKPKBProtein kinase BPeroxisome proliferator-activated receptorsKcsAEnvironmental ContaminantsNitric oxide synthasesNOSExtracellular signal regulated kinasesAMP-activated protein kinase3T3-L1RAW264.7C57BL/6 mousesepsisvasoconstrictionInhibitorinhibitorinhibit

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