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Results for "

galnac

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Amino Acid Derivatives (4) Apolipoprotein (4) Apoptosis (1) Asialoglycoprotein Receptor (ASGPR) (3) Biochemical Assay Reagents (29) Complement System (1) DNA/RNA Synthesis (3) Drug Derivative (2) Drug Intermediate (4) Endogenous Metabolite (7) Epigenetic Reader Domain (1) Factor Xa (1) Fluorescent Dye (2) Galectin (1) Glucosylceramide Synthase (GCS) (1) Glycosidase (1) Glycosyltransferase (2) HBV (3) Lactate Dehydrogenase (2) LYTACs (12) Mucin (2) Nucleoside Antimetabolite/Analog (2) OGT (1) PCSK9 (2) Phosphatase (1) Phosphoramidites (3) PROTACs (1) Reference Standards (1) Ser/Thr Protease (3) Sialyltransferase (1) Small Interfering RNA (siRNA) (17) TMPRSS6 (2) Transthyretin (TTR) (4) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (7) Infection (4) Inflammation/Immunology (7) Metabolic Disease (16) Neurological Disease (4)
Click Chemistry:	DBCO (2) Azide (4)
Oligonucleotides:	Nucleotide Analogs (2) Nucleoside Analogs (1) Adenine (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNA drugs (13) Antisense Oligonucleotides (6) Other Phosphoramidite (2) Phosphoramidites (3) siRNAs (18)

100

Inhibitors & Agonists

Fluorescent Dye

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Antibodies

Click Chemistry

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129389

Benzyl-α-GalNAc Maximum Cited Publications 7 Publications Verification	Glycosyltransferase	Cancer
Benzyl-α-GalNAc is a potent O-glycosylation inhibitor. Benzyl-α-GalNAc effectively inhibits the proliferation and activation of LX-2 cells and suppresses the expression of collagen I/III, which has good potential for investigation in liver fibrosis. Benzyl-α-GalNAc also significantly enhances the anti-tumour activity of 5-Fluorouracil (HY-90006) (e.g. pancreatic cancer) by inhibiting O-glycosylation .

HY-145934

UDP-GalNAz disodium 1 Publications Verification UDP-N-azidoacetylgalactosamine disodium	Biochemical Assay Reagents OGT Glycosidase	Metabolic Disease
UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-148476

*Tri-GalNAc-DBCO*	LYTACs	Metabolic Disease
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .

HY-114365

*UDP-GalNAc* disodium** 1 Publications Verification UDP-N-acetyl-D-galactosamine disodium	Endogenous Metabolite	Metabolic Disease Cancer
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate for EpsC115. EpsC115 is a mutant with N-terminal residues 1-115 deleted from the exopolymeric substance (EPS). UDP-GalNAc disodium is a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from nucleotide sugars to sugar or peptide acceptors. UDP-GalNAc disodium provides a sugar group donor for glycosylation reactions. UDP-GalNAc disodium can be used in cancer research, such as colorectal and breast cancer .

HY-148118A

*Tri-GalNAc(OAc)3 TFA*	LYTACs	Cancer
Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .

HY-150223

GalNAc unconjugated/naked Inclisiran 1 Publications Verification	PCSK9 Small Interfering RNA (siRNA)	Cardiovascular Disease
GalNAc unconjugated/naked Inclisiran is a double-stranded small interfering RNA molecule that targets hepatic PCSK9 production to reduce LDL-C levels. GalNAc unconjugated/naked Inclisiran can be used in the research of cardiovascular diseases and hypercholesterolemia .

HY-E70285

beta-1,4-Galactosyltransferase 1 (Y285L) B4GALT1 (Y285L)	Endogenous Metabolite	Metabolic Disease
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc .

HY-148089

Eplontersen 1 Publications Verification	Transthyretin (TTR)	Neurological Disease
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-P0232

*Fmoc-Thr[GalNAc(Ac)3-α-D]-OH* Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Amino Acid Derivatives	Inflammation/Immunology Cancer
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-148118

*Tri-GalNAc(OAc)3*	LYTACs	Cancer
Tri-GalNAc(OAc)3 is a trivalent N-acetylgalactosamine (tri-GalNAc) derivative, which can be used as a linker to synthesize LYTACs .

HY-104004

*Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH* Fmoc-Ser-(galnac(Ac)3-alpha-D)-OH; Fmoc-Ser[galnac(Ac)3-α-D]-OH; Fmoc-Ser(Ac3AcNH-α-Gal)-OH	Amino Acid Derivatives Drug Intermediate	Cancer
Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH (Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH) is a protected glycosylated amino acid and Tn antigen. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH serves as a building block in the solid-phase synthesis of Tn-based cancer vaccine constructs. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH supports solid-phase peptide synthesis .

HY-132606A

Nedosiran sodium DCR-PHXC sodium	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-147012

GalNAc-L96	Drug Intermediate	Others
GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-139482

*tri-GalNAc-COOH*	LYTACs	Cancer
tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .

HY-147354

TriGalNAc CBz	LYTACs	Cardiovascular Disease
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies .

HY-151863

*alpha-GalNAc-TEG-N3*	ADC Linker	Others
alpha-GalNAc-TEG-N3 is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151123A

Pelacarsen sodium AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium	Apolipoprotein DNA/RNA Synthesis	Metabolic Disease
Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) .

HY-128852

N-Acetyl-D-galactosamine, 98%	Galectin Endogenous Metabolite	Others
N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets . N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin .

HY-153491

Olezarsen ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx	Apolipoprotein	Cardiovascular Disease
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .

HY-160109

Ac5GalNTGc 1 Publications Verification	Mucin	Inflammation/Immunology Cancer
Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .

HY-173247

GalNAc-NAG37 phosphoramidite	Drug Derivative	Others
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery .

HY-E70032

N-Acetylhexosamine kinase (NahK)	Endogenous Metabolite	Metabolic Disease
N-Acetylhexosamine kinase (NahK) is an anomeric kinase acting on a glucose-type substrate. N-Acetylhexosamine kinase catalyzes the phosphorylation of GlcNAc or GalNAc at the anomeric C1 position with ATP to form N-acetylhexosamine 1-phosphate (GlcNAc-1P/GalNAc-1P) .

HY-148089A

Eplontersen sodium 1 Publications Verification	Transthyretin (TTR)	Neurological Disease
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-P3443

Peanut agglutinin 1 Publications Verification PNA	Biochemical Assay Reagents	Cancer
Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions .

HY-153492A

Olpasiran sodium AMG 890 sodium; ARC-LPA sodium	Small Interfering RNA (siRNA)	Inflammation/Immunology
Olpasiran (AMG 890, ARC-LPA) sodium is an N-acetyl galactosamine (GalNAc)-conjugated, hepatocyte-targeted siRNA. Olpasiran sodium directly inhibits LPA messenger RNA translation in hepatocytes and potently reduce Lp(a) concentration. Olpasiran sodium can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-147266

Elebsiran sodium VIR-2218 sodium	Small Interfering RNA (siRNA) HBV	Infection
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

HY-153491A

Olezarsen sodium ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium	Apolipoprotein	Cardiovascular Disease
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .

HY-147102

*tri-GalNAc* biotin**	LYTACs	Metabolic Disease
tri-GalNAc biotin is a biotinylated ASGPR (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC) .

HY-145368B

*Tri-GalNAc(OAc)3-Perfluorophenyl*	LYTACs	Metabolic Disease
Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation.Tri-GalNAc(OAc)3-Perfluorophenyl can be used for the study of liver metabolism .

HY-150151A

GalNac-siRNA negative control (21nt)	LYTACs	Cardiovascular Disease
GalNac-siRNA negative control (21nt) is the negative control form of GalNac-siRNA. GalNac-siRNA is an Asialoglycoprotein receptor (ASGPR)-targeted inhibitor conjugate. GalNac-siRNA is promising for research of hereditary transthyretin amyloidosis, acute hepatic porphyria, hemophilia and hypercholesterolemia .

HY-143220

*SS(no Galnac)-Inclisiran sodium*	PCSK9	Cardiovascular Disease
SS(no Galnac)-Inclisiran (sodium) is a single stran Inclisiran with no GalNAc. Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9 .

HY-150224

GalNAc unconjugated/naked Fitusiran sodium	Small Interfering RNA (siRNA) Factor Xa	Others
GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia .

HY-132590A

Revusiran sodium ALN-TTRSC sodium	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Revusiran (ALN-TTRSC) sodium is an RNA interference agent targeting the mRNA of transthyretin (Transthyretin, TTR). Revusiran sodium mediates sequence-specific degradation of TTR mRNA through RNA interference, reduces the synthesis of TTR protein, binds to *GalNAc* ligands, and is taken up by hepatocytes via the asialoglycoprotein receptor. Revusiran sodium exhibits favorable nonclinical safety profiles. Revusiran sodium can be used in studies related to transthyretin-mediated amyloidosis .

HY-153184

GalNAc-L96 free base	Asialoglycoprotein Receptor (ASGPR) Small Interfering RNA (siRNA)	Metabolic Disease
GalNAc-L96 free base is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 free base binds potently to ASGPR, with a K_i value of 10.4 nM. GalNAc-L96 free base promotes siRNA delivery to hepatocytes .

HY-160291

*Trivalent GalNAc-DBCO*	Biochemical Assay Reagents	Others
Trivalent GalNAc-DBCO can be used for oligonucleotide coupling .

HY-W015996

4-Nitrophenyl-N-acetyl-α-D-galactosaminide pNP-galnac	Fluorescent Dye	Others
4-Nitrophenyl-N-acetyl-α-D-galactosaminide (pNP-GalNAc) can be used as a chromogenic substrate for N-acetyl-D-galactosaminase. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide is cleaved by N-acetyl-D-galactosaminase to generate a yellow solution. The enzyme activity is quantitatively determined by absorbance detection .

HY-171910

*tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12)*	Asialoglycoprotein Receptor (ASGPR) LYTACs	Others
tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .

HY-151123

Pelacarsen AKCEA-APO(a)-LRx; ISIS 681257; TQJ230	Apolipoprotein DNA/RNA Synthesis	Metabolic Disease
Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a) .

HY-145720A

Cemdisiran sodium ALN-CC5 sodium	Complement System	Others
Cemdisiran sodium is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-132606

Nedosiran DCR-PHXC	Small Interfering RNA (siRNA) Lactate Dehydrogenase	Metabolic Disease
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

HY-E70290

N-Acetylgalactosaminyltransferase 1 GALNT1	Endogenous Metabolite β-catenin Wnt	Cancer
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .

HY-154790

STn/sialyl-Tn Neu5Aca2-6galnac-a-Ser/Thr	Ser/Thr Protease	Cancer
STn/sialyl-Tn is a sialic acid associated with breast cancer and its expression is closely related to HER2-pos. STn/sialyl-Tn can be used as a marker to count cells in malignant nipple discharge (PND) .

HY-W1008621

GalNAc-THA C6 phosphoramidite	Biochemical Assay Reagents	Others
GalNAc-THA C6 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to Trishexylamino (THA), which can be used for the synthesis of oligonucleotides.

HY-137823

4-Nitrophenyl-N-acetyl-β-D-galactosaminide	Endogenous Metabolite	Cancer
4-Nitrophenyl-N-acetyl-β-D-galactosaminide has inhibitory activity against GlcNAc and *GalNAc* with K_is of 1.15 mM and 0.51 mM, respectively. 4-Nitrophenyl-N-acetyl-β-D-galactosaminide is extracted from Trichomonas foetus (T. foetus)

HY-147266A

Elebsiran VIR-2218	HBV Small Interfering RNA (siRNA)	Infection
Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections .

HY-147278

Manusiran Divesiran; SLN124	Ser/Thr Protease Small Interfering RNA (siRNA) TMPRSS6	Cardiovascular Disease
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .

HY-145013

*tri-GalNAc-COOH (acetylation)*	LYTACs	Others
tri-GalNAc-COOH acetylation is the acetylated and modified form of tri-GalNAc-COOH. tri-GalNAc-COOH acetylation can be used for the synthesis of LYTAC.

HY-W145586

*GlcNAcβ(1-3)GalNAc-α-Thr* GlcNAc beta(1-3)galnac-alpha-Thr	Biochemical Assay Reagents	Others
GlcNAcβ(1-3)GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145534

*GlcNAcβ(1-3)GalNAc-α-pNP*	Biochemical Assay Reagents	Others
GlcNAcβ(1-3)GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P5045

*Fmoc-Thr(GalNAc(Ac)3-β-D)-OH*	Amino Acid Derivatives	Inflammation/Immunology Cancer
Fmoc-Thr(GalNAc(Ac)3-β-D)-OH inhibits cancer cell growth, through targeting intricate cancer-specific pathways while simultaneously strengthening immunologic response .

Cat. No.	Product Name	Type

HY-W015996

4-Nitrophenyl-N-acetyl-α-D-galactosaminide pNP-galnac	Fluorescent Dye
4-Nitrophenyl-N-acetyl-α-D-galactosaminide (pNP-GalNAc) can be used as a chromogenic substrate for N-acetyl-D-galactosaminase. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide is cleaved by N-acetyl-D-galactosaminase to generate a yellow solution. The enzyme activity is quantitatively determined by absorbance detection .

HY-W116594

X-GalNAc	Fluorescent Dye
X-GalNAc is a chromogenic substrate for for N-acetyl-β-galactosidase, used to determine the presence or absence of a cloned DNA insert in bacteria growing on agar plates .

Cat. No.	Product Name	Type

HY-114365

UDP-GalNAc disodium

1 Publications Verification

UDP-N-acetyl-D-galactosamine disodium

Biochemical Assay Reagents

UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate for EpsC115. EpsC115 is a mutant with N-terminal residues 1-115 deleted from the exopolymeric substance (EPS). UDP-GalNAc disodium is a donor substrate for many N-acetylgalactosaminyltransferases, which transfer GalNAc from nucleotide sugars to sugar or peptide acceptors. UDP-GalNAc disodium provides a sugar group donor for glycosylation reactions. UDP-GalNAc disodium can be used in cancer research, such as colorectal and breast cancer .

HY-128852

N-Acetyl-D-galactosamine, 98%

Biochemical Assay Reagents

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets . N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin .

HY-173247

GalNAc-NAG37 phosphoramidite	Biochemical Assay Reagents
GalNAc-NAG37 phosphoramidite is an N-acetylgalactosamine (GalNAc) derivative that acts as a ligand for the asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and for oligonucleotide delivery .

HY-P3443

Peanut agglutinin

1 Publications Verification

PNA

Biochemical Assay Reagents

Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions .

HY-W1008621

GalNAc-THA C6 phosphoramidite	Biochemical Assay Reagents
GalNAc-THA C6 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to Trishexylamino (THA), which can be used for the synthesis of oligonucleotides.

HY-W145586

*GlcNAcβ(1-3)GalNAc-α-Thr* GlcNAc beta(1-3)galnac-alpha-Thr	Biochemical Assay Reagents
GlcNAcβ(1-3)GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145534

*GlcNAcβ(1-3)GalNAc-α-pNP*	Biochemical Assay Reagents
GlcNAcβ(1-3)GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-NP186A

Helix pomatia Agglutinin (Biotin) HPA (Biotin)	Biochemical Assay Reagents
Helix pomatia Agglutinin (Biotin) (HPA (Biotin)) is a biotinylated hexameric glycoprotein that is specific for N-acetylgalactosamine (GalNAc) .

HY-173248

GalNAc-NAG15 phosphoramidite	Biochemical Assay Reagents
GalNAc-NAG-15 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.

HY-173246

GalNAc-NAG25 phosphoramidite	Biochemical Assay Reagents
GalNAc-NAG-25 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.

HY-E70139

*UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2* EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II	Biochemical Assay Reagents
UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase .

HY-E70142

Glucosaminyl (N-acetyl) Transferase 1 EC:2.4.1.102; GCNT1	Biochemical Assay Reagents
Glucosaminyl (N-acetyl) Transferase 1 ( EC:2.4.1.102, GCNT1) is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch and play an important role in cancer .

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Biochemical Assay Reagents
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-W145607

*Galβ(1-3)GalNAc-β-pNP* Gal beta(1-3)galnac-beta-pNP	Biochemical Assay Reagents
Galβ(1-3)GalNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145655

*Gal-β1,3-GalNAc-α1-OBn*	Biochemical Assay Reagents
Gal-β1,3-GalNAc-α1-OBn is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70151

ST6 Sialyltransferase 2 ST6galnac2	Biochemical Assay Reagents
ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

HY-W145539

*GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr* GlcNAc beta(1-3)[GlcNAc beta(1-6)]galnac-alpha-Thr	Biochemical Assay Reagents
GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W698411

GlcNAc1-β-6GalNAc-α-PNP

Biochemical Assay Reagents

GlcNAc1-β-6GalNAc-α-PNP is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W145631

GalNAcβ(1-4)GlcNAc-β-pNP galnac beta(1-4)GlcNAc-beta-pNP	Biochemical Assay Reagents
GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145540

*Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP*	Biochemical Assay Reagents
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W698908

GalNAc1-b-3Gal-α-Ome

Methyl 3-O-[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]-α-D-galactopyranoside

Biochemical Assay Reagents

GalNAc1-b-3Gal-α-Ome (Methyl 3-O-[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]-α-D-galactopyranoside) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-E70152

ST6 Sialyltransferase 4 EC:2.4.3.7; ST6galnac4; SIAT3-C	Biochemical Assay Reagents
ST6 Sialyltransferase 4 (EC:2.4.3.7; ST6GALNAC4; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. ST6 Sialyltransferase 4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation. .

HY-E70163

Carbohydrate Sulfotransferase 3 EC:2.8.2.17; CHST3; C6ST1	Biochemical Assay Reagents
Carbohydrate Sulfotransferase 3 (EC:2.8.2.17) can catalyze sulphate transfer to position 6 of GalNAc residue of chondroitin .

HY-E70167

Carbohydrate Sulfotransferase 7 EC:2.8.2.17; CHST7; GlcNAc6ST-4	Biochemical Assay Reagents
Carbohydrate Sulfotransferase 7 (EC:2.8.2.17) can catalyze sulphate transfer to position 6 of non- GlcNAc residues and to position 6 of the GalNAc residue of chondroitin .

HY-NP186

Helix pomatia Agglutinin

Biochemical Assay Reagents

Helix pomatia Agglutinin is a N-acetylgalactosamine (GalNAc) binding lectin, found in the reproductive gland of a Roman snail. Helix pomatia Agglutinin binds with high affinity (k_D = 1.9-2.4 μM) steroid hormones: testosterone and progesterone. Helix pomatia Agglutinin interacts with adenine (k_D = 5.4 μM) and arylaminonaphthalene sulfonate TNS (k_D = 12 μM). Helix pomatia Agglutinin is commonly used for characterizing, imaging, or targeting glycoconjugates, and is also a very useful tool for glycomics analysis . Helix pomatia Agglutinin can be used for cancer prognosis study .

HY-W779188

GlcNAc1-β-3GalNAc	Biochemical Assay Reagents
GlcNAc1-β-3GalNAc is a biochemical assay reagent.

HY-W145663

*Gal-β1,3-GalNAc-β-OMe*	Biochemical Assay Reagents
Gal-β1,3-GalNAc-β-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145553

GalNAcβ(1-3)GlcNAc-β-pNP	Biochemical Assay Reagents
GalNAcβ(1-3)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W698547

2-(Acetylamino)-2-deoxy-3-O-α-D-galactopyranosyl-D-galactose galnacβ1-3Gal	Biochemical Assay Reagents
2-(Acetylamino)-2-deoxy-3-O-α-D-galactopyranosyl-D-galactose (GalNAcβ1-3Gal) is a biochemical assay reagent.

Cat. No.	Product Name	Target	Research Area

HY-P0232

*Fmoc-Thr[GalNAc(Ac)3-α-D]-OH* Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Amino Acid Derivatives	Inflammation/Immunology Cancer
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P5045

*Fmoc-Thr(GalNAc(Ac)3-β-D)-OH*	Amino Acid Derivatives	Inflammation/Immunology Cancer
Fmoc-Thr(GalNAc(Ac)3-β-D)-OH inhibits cancer cell growth, through targeting intricate cancer-specific pathways while simultaneously strengthening immunologic response .

HY-P5508

MUC5AC-13	Peptides	Others
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc* from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)

HY-P5511

MUC5AC-3/13	Peptides	Others
MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

HY-P5512

MUC5AC-3	Peptides	Others
MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

HY-P5473

EA2	Peptides	Others
EA2 is a biological active peptide. (This is a peptide substrate for polypeptide N-acetylgalactosaminyltransferase (polypeptide GalNAc-T).)

Cat. No.	Product Name

HY-KE7057

O-Glycosidase
O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.

HY-KE8012

Protein Deglycosylation Kit(for O-linked Glycans)

Protein Deglycosylation Kit (for O-linked Glycans)contains O-Glycosidase and a2-3,6,8,9 Neuraminidase.Both enzymes are crucial tool enzymes for glycosylation research and are used in combination to enzymatically release O-linked glycans from glycoproteins.O-Glycosidase is capable of cleaving and releasing Core 1 (Gal-B(1-3)-GalNAc-)and Core 3(GIcNAc-B(1-3)-GalNAc-)O-linked disaccharides,which are linked to the hydroxyl groups of Ser or Thr residues in glycoproteins.a2-3,6,8,9 Neuraminidase can remove a(2,3)-,a(2,6)-,a(2,8)-,and a(2,9)-sialic acid residues from the non-reducing termini of O-linked glycans.

Species:	Human (9) Mouse (1)
Tag:	His (10) HA (1)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71333

	ST6GALNAC2 Protein, Mouse (HEK293, His) Gal-beta-1,3-galnac alpha-2,6-sialyltransferase,galnac alpha-2,6-sialyltransferase II,ST6galnac II,Sialyltransferase 7B,SIAT7-B	Mouse	HEK293
	ST6GALNAC2 Protein, an enzyme, is involved in the process of glycosylation.It adds a specific sugar molecule to proteins and lipids, influencing their functions in cell signaling and adhesion.ST6GALNAC2 Protein is also implicated in certain diseases and may serve as a potential target for therapeutic interventions.ST6GALNAC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ST6GALNAC2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71332

	ST6GALNAC2 Protein, Human (HEK293, His) Alpha-N-Acetylgalactosaminide Alpha-2; 6-Sialyltransferase 2; galnac Alpha-2; 6-Sialyltransferase II; ST6galnac II; ST6galnacII; SThM; Sialyltransferase 7B; SIAT7-B; ST6galnac2; SIAT7B; SIATL1; STHM	Human	HEK293
	The ST6GALNAC2 protein is an essential enzyme that catalyzes the transfer of N-acetylneuramidyl groups to glycan chains in glycoproteins. This glycosyltransferase shows a preference for N-acetylgalactosamine (GalNAc) residues that have been modified by the addition of galactose or galactose followed by the addition of sialic acid in an α-2,3 linkage. ST6GALNAC2 Protein, Human (HEK293, His) is the recombinant human-derived ST6GALNAC2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70831

	GALNT3 Protein, Human (HEK293, His) Polypeptide N-acetylgalactosaminyltransferase 3; Polypeptide galnac transferase 3; galnac-T3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-galnac:polypeptide N-acetylgalactosaminyltransferase 3; HFTC; HHS	Human	HEK293
	GALNT3 Protein initiates O-linked oligosaccharide biosynthesis by transferring an N-acetyl-D-galactosamine residue to serine or threonine on protein receptors, including HIV envelope glycoproteins (gp120), EA2, MUC2, MUC1A, MUC5AC, and possibly fibronectin. GALNT3 also glycosylates FGF23 in vivo. GALNT3 Protein, Human (HEK293, His) is the recombinant human-derived GALNT3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70877

	GALNTL1 Protein, Human (HEK293, His) Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1; Polypeptide galnac Transferase-Like Protein 1; galnac-T-Like Protein 1; pp-GaNTase-Like Protein 1; Protein-UDP Acetylgalactosaminyltransferase-Like Protein 1; UDP-galnac:Polypeptide N-Acety	Human	HEK293
	GALNTL1 protein plays a pivotal role in O-linked oligosaccharide biosynthesis by catalyzing the crucial initial step—the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. This enzymatic activity is fundamental for the glycosylation processes that modulate the structure and function of various proteins, impacting diverse cellular functions. GALNTL1 Protein, Human (HEK293, His) is the recombinant human-derived GALNTL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76354

	GALNT10 Protein, Human (HEK293, His) Polypeptide N-acetylgalactosaminyltransferase 10; galnac-T10	Human	HEK293
	GALNT10 protein assumes a crucial role in the initiation of O-linked oligosaccharide biosynthesis, facilitating the transfer of an N-acetyl-D-galactosamine residue to specific serine or threonine residues on protein receptors. With its catalytic activity, GALNT10 demonstrates specificity towards substrates such as Muc5Ac and EA2 peptides, contributing to the intricate process of protein glycosylation and subsequent cellular functions. GALNT10 Protein, Human (HEK293, His) is the recombinant human-derived GALNT10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76355

	GALNT2 Protein, Human (HEK293, His) Polypeptide N-acetylgalactosaminyltransferase 2; galnac-T2	Human	HEK293
	The GALNT2 protein catalyzes the initial steps in O-linked oligosaccharide biosynthesis by transferring N-acetyl-D-galactosamine to a protein receptor. GALNT2 Protein, Human (HEK293, His) is the recombinant human-derived GALNT2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76258

	CHST15 Protein, Human (HEK293, His) Carbohydrate sulfotransferase 15; hBRAG; galnac4S-6ST; BRAG	Human	HEK293
	The CHST15 protein is a sulfotransferase that catalyzes the transfer of sulfate to GalNAc 4-sulfate in chondroitin sulfate A to form chondroitin sulfate E with GlcA-GalNAc(4,6-SO(4)) units. It also sulfates the unique non-reducing terminal sequence GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), similar to thrombomodulin chondroitin sulfate. CHST15 Protein, Human (HEK293, His) is the recombinant human-derived CHST15 protein, expressed by HEK293 , with N-His labeled tag.

HY-P70867

	GALNT7 Protein, Human (HEK293, His) Polypeptidegalnac-transferase7; Protein-UDP acetylgalactosaminyltransferase7; UDP-galnac:polypeptide N-acetylgalactosaminyltransferase 7; GALNT7.	Human	HEK293
	The GALNT7 protein serves as an indispensable glycopeptidyl transferase for O-linked oligosaccharide biosynthesis. Its enzymatic activity involves catalyzing the transfer of N-acetyl-D-galactosamine residues to pre-existing glycosylated peptides. GALNT7 Protein, Human (HEK293, His) is the recombinant human-derived GALNT7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70404

	N-acetylgalactosamine kinase/GALK2 Protein, Human (HEK293, His) rHuN-acetylgalactosamine kinase/GALK2, His; N-acetylgalactosamine kinase; galnac kinase; Galactokinase 2; GALK2 and GK2	Human	HEK293
	N-acetylgalactosamine kinase (GALK2) has dual enzymatic roles, acting on N-acetylgalactosamine (GalNAc) and functioning as a galactokinase under high galactose concentrations. GALK2 is implicated in a potential salvage pathway, facilitating the reutilization of free GalNAc from the breakdown of complex carbohydrates. N-acetylgalactosamine kinase/GALK2 Protein, Human (HEK293, His) is the recombinant human-derived N-acetylgalactosamine kinase/GALK2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77849

	ST3GAL4 Protein, Human (HEK293, His-HA) Sialyltransferase 4C; SIAT4; SIAT4C; SIAT4-C; ST3Gal IV; ST3GAL4; ST3GalA.2; ST-4; STZSIAT4; Alpha 2,3-ST 4; CGS23; CGS23FLJ46764; FLJ11867; Gal-NAc 6S; NANTA3; SAT3; SAT-3	Human	HEK293
	The ST3GAL4 protein is a β-galactoside α2-3 sialyltransferase essential for the sialylation of glycoproteins and glycolipids. It mediates hemostasis by sialylating VWF, preventing ASGPR recognition and clearance, and regulating platelet clearance. ST3GAL4 Protein, Human (HEK293, His-HA) is the recombinant human-derived ST3GAL4 protein, expressed by HEK293 , with C-His, N-HA labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (3)
Reactivity:	Human (2) Mouse (2) Monkey (2) human (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (1) IP (1) WB (3) FC (2) ELISA (3)
Isotype:	IgG1 (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal Antibody (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89661

	GalNAc-T14 Antibody (YA9005)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	GalNAc-T14 Antibody (YA9005) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GalNAc-T14.

HY-P84452

	B4GALNT1 Antibody (YA4149) GALGT; SPG26; galnacT; galnac-T	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	B4GALNT1 Antibody (YA4149) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to B4GALNT1.

HY-P84452A

	B4GALNT1 Antibody (YA4149)(PBS only) GALGT; SPG26; galnacT; galnac-T	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey
	B4GALNT1 Antibody (YA4149) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to B4GALNT1.

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Products	In-stock - + Add to Cart
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Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
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SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-145934

UDP-GalNAz disodium 1 Publications Verification UDP-N-azidoacetylgalactosamine disodium		Azide
UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-148476

*Tri-GalNAc-DBCO*		DBCO
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units connected to DBCO. Tri-GalNAc-DBCO can act as a ligand for the sialic acid-degrading protein receptor (ASGPR), and can be coupled with targeting proteins or small molecules to form GalNAc-LYTACs. Tri-GalNAc-DBCO specifically binds to ASGPR and, through receptor-mediated endocytosis, guides the coupled molecules to lysosomes for degradation .

HY-151863

*alpha-GalNAc-TEG-N3*		Azide
alpha-GalNAc-TEG-N3 is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-160291

*Trivalent GalNAc-DBCO*		DBCO
Trivalent GalNAc-DBCO can be used for oligonucleotide coupling .

HY-178685

*Peracetylated GalNAc* PEG linker-azide**		Azide
Peracetylated GalNAc PEG linker-azide is a monomeric raw material that can be used for nucleic acid synthesis.

HY-173261

*Tri-GalNAc(OAc)3-Cbz*		Azide
Tri-GalNAc(OAc)3-Cbz is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name		Classification

HY-145934

UDP-GalNAz disodium 1 Publications Verification UDP-N-azidoacetylgalactosamine disodium		Nucleotide Analogs
UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc disodium (HY-114365). UDP-GalNAc disodium is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GalNAz disodium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-150223

GalNAc unconjugated/naked Inclisiran 1 Publications Verification		siRNAs siRNA drugs
GalNAc unconjugated/naked Inclisiran is a double-stranded small interfering RNA molecule that targets hepatic PCSK9 production to reduce LDL-C levels. GalNAc unconjugated/naked Inclisiran can be used in the research of cardiovascular diseases and hypercholesterolemia .

HY-148089

Eplontersen 1 Publications Verification		Antisense Oligonucleotides
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-132606A

Nedosiran sodium DCR-PHXC sodium		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate .

HY-151123A

Pelacarsen sodium AKCEA-APO(a)-LRx sodium; ISIS 681257 sodium; TQJ230 sodium		Antisense Oligonucleotides
Pelacarsen sodium (ISIS 681257 sodium) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen sodium reduces apo (a) .

HY-153491

Olezarsen ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx		Antisense Oligonucleotides
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .

HY-148089A

Eplontersen sodium 1 Publications Verification		Antisense Oligonucleotides
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-153492A

Olpasiran sodium AMG 890 sodium; ARC-LPA sodium		siRNAs siRNA drugs
Olpasiran (AMG 890, ARC-LPA) sodium is an N-acetyl galactosamine (GalNAc)-conjugated, hepatocyte-targeted siRNA. Olpasiran sodium directly inhibits LPA messenger RNA translation in hepatocytes and potently reduce Lp(a) concentration. Olpasiran sodium can be used for the research of cardiovascular disease, such as atherosclerosis .

HY-147266

Elebsiran sodium VIR-2218 sodium		siRNAs siRNA drugs
Elebsiran (VIR-2218) sodium is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran sodium leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran sodium binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran sodium can be used for the study of chronic HBV/HDV infections .

HY-153491A

Olezarsen sodium ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium		Antisense Oligonucleotides
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .

HY-150151A

GalNac-siRNA negative control (21nt)		siRNAs siRNA drugs
GalNac-siRNA negative control (21nt) is the negative control form of GalNac-siRNA. GalNac-siRNA is an Asialoglycoprotein receptor (ASGPR)-targeted inhibitor conjugate. GalNac-siRNA is promising for research of hereditary transthyretin amyloidosis, acute hepatic porphyria, hemophilia and hypercholesterolemia .

HY-143220

*SS(no Galnac)-Inclisiran sodium*		siRNAs siRNA drugs
SS(no Galnac)-Inclisiran (sodium) is a single stran Inclisiran with no GalNAc. Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9 .

HY-150224

GalNAc unconjugated/naked Fitusiran sodium		siRNAs siRNA drugs
GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia .

HY-132590A

Revusiran sodium ALN-TTRSC sodium		siRNAs siRNA drugs
Revusiran (ALN-TTRSC) sodium is an RNA interference agent targeting the mRNA of transthyretin (Transthyretin, TTR). Revusiran sodium mediates sequence-specific degradation of TTR mRNA through RNA interference, reduces the synthesis of TTR protein, binds to *GalNAc* ligands, and is taken up by hepatocytes via the asialoglycoprotein receptor. Revusiran sodium exhibits favorable nonclinical safety profiles. Revusiran sodium can be used in studies related to transthyretin-mediated amyloidosis .

HY-151123

Pelacarsen AKCEA-APO(a)-LRx; ISIS 681257; TQJ230		Antisense Oligonucleotides
Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2′-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a) .

HY-145720A

Cemdisiran sodium ALN-CC5 sodium		siRNAs siRNA drugs
Cemdisiran sodium is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the research of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

HY-132606

Nedosiran DCR-PHXC		siRNAs siRNA drugs
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .

HY-147278

Manusiran Divesiran; SLN124		siRNAs siRNA drugs
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .

HY-132590

Revusiran ALN-TTRSC		siRNAs siRNA drugs
Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research .

HY-173248

GalNAc-NAG15 phosphoramidite		Phosphoramidites Other Phosphoramidite
GalNAc-NAG-15 phosphoramidite is a phosphoramidite derivative containing N-acetylgalactosamine (GalNAc) part linked to NAG, which can be used for the synthesis of oligonucleotides.

HY-147278A

Manusiran sodium Divesiran sodium; SLN124 sodium		siRNAs siRNA drugs
Manusiran (SLN124) sodium, a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels ^[1][2].

HY-RS16340

ST6GALNAC4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ST6GALNAC4 Human Pre-designed siRNA Set A contains three designed siRNAs for ST6GALNAC4 gene (Human), as well as a negatST6GALNAC4e control, a positST6GALNAC4e control, and a FAM-labeled negatST6GALNAC4e control.

HY-RS16289

St6galnac4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
St6galnac4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for St6galnac4 (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control. Components St6galnac4 siRNA-1: 5 nmol (HPLC) St6galnac4 siRNA-2: 5 nmol (HPLC) St6galnac4 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control: 5 nmol (HPLC)

HY-RS25595

St6galnac1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
St6galnac1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for St6galnac1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16361

ST6GALNAC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ST6GALNAC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ST6GALNAC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16328

St6galnac4 Rat Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
St6galnac4 Rat Pre-designed siRNA Set A contains three designed siRNAs for St6galnac4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-160011

GalNAc-5 phosphoramidite		Phosphoramidites Other Phosphoramidite
GalNAc-5 phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-178607

*AdemA-GalNAc* phosphoramidite**		Phosphoramidites Adenine
AdemA-GalNAc phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

HY-178685

*Peracetylated GalNAc* PEG linker-azide**		Nucleoside Analogs Nucleotide Analogs
Peracetylated GalNAc PEG linker-azide is a monomeric raw material that can be used for nucleic acid synthesis.

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