2. Epigenetics
  3. Small Interfering RNA (siRNA)
  4. Nedosiran

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate.

For research use only. We do not sell to patients.

RNA,(Am-sp-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)U-Gm-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Um-Gm-Am-Gm-Cm-Am-GmCm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-GmCm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')- sp-(2'-deoxy-2'-fluoro)C-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G- (2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-(2'-deo

Nedosiran Chemical Structure

CAS No. : 2266591-83-5

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Nedosiran Related Antibodies

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Description

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate[1][2][3].

In Vitro

Nedosiran (DCR-PHXC) is an investigational ribonucleic acid interference (RNAi) therapy[2].
Nedosiran is a synthetic, double-stranded RNA oligonucleotide (i.e., small interfering RNA [siRNA]) designed to target the mRNA encoding LDHA[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nedosiran Related Antibodies
In Vivo

Nedosiran is a RNAi therapy for primary hyperoxaluria that selectively reduce hepatic expression of lactate dehydrogenase[3].
Nedosiran specially inhibits hepatic expression of lactate dehydrogenase (LDHA)[3].
Nedosiran is a double-strand siRNA molecule that is conjugated with GalNAc, which takes advantage of the aforementioned unique asialoglycoprotein receptor (ASGPR) delivery system in the liver. Nedosiran is administered by monthly subcutaneous injection. Nedosiran decreases plasma oxalate in animal models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

20985.00

CAS No.
SMILES

[Nedosiran]
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nedosiran Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nedosiran2266591-83-5DCR-PHXCSmall Interfering RNA (siRNA)lactatedehydrogenaseRNAinterferenceInhibitorinhibitorinhibit

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