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Revusiran (Synonyms: ALN-TTRSC)

Cat. No.: HY-132590
Handling Instructions

Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research.

For research use only. We do not sell to patients.

Revusiran Chemical Structure

Revusiran Chemical Structure

CAS No. : 1438322-82-7

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Description

Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research[1].

In Vitro

Revusiran is a chemically synthesized double-stranded siRNA that is covalently linked at the 3′-end of its sense strand to a ligand containing three GalNAc residues. Revusiran is a 1st-generation short interfering RNA targeting transthyretin conjugated to an N-acetylgalactosamine ligand to facilitate delivery to hepatocytes via uptake by the asialoglycoprotein receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

There are no effects on cardiovascular or respiratory function in monkeys after single doses of up to 100 mg/kg. No neurological effects weare noted in monkeys in repeat-dose studies up to 300 mg/kg. Revusiran is well tolerated in repeat-dose mouse (weekly doses) and rat and monkey (five daily doses followed by weekly doses) toxicity studies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Revusiran
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