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  4. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH  (Synonyms: Fmoc-Thr(Ac₃AcNH-α-Gal)-OH)

Cat. No.: HY-P0232 Purity: 98.36%
COA Handling Instructions

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AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Chemical Structure

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Chemical Structure

CAS No. : 116783-35-8

Size Price Stock Quantity
25 mg USD 336 In-stock
50 mg USD 576 In-stock
100 mg USD 816 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

In Vitro

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Related Antibodies
Molecular Weight

670.66

Formula

C33H38N2O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (149.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4911 mL 7.4553 mL 14.9107 mL
5 mM 0.2982 mL 1.4911 mL 2.9821 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.36%

COA (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4911 mL 7.4553 mL 14.9107 mL 37.2767 mL
5 mM 0.2982 mL 1.4911 mL 2.9821 mL 7.4553 mL
10 mM 0.1491 mL 0.7455 mL 1.4911 mL 3.7277 mL
15 mM 0.0994 mL 0.4970 mL 0.9940 mL 2.4851 mL
20 mM 0.0746 mL 0.3728 mL 0.7455 mL 1.8638 mL
25 mM 0.0596 mL 0.2982 mL 0.5964 mL 1.4911 mL
30 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2426 mL
40 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.9319 mL
50 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7455 mL
60 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.6213 mL
80 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.4660 mL
100 mM 0.0149 mL 0.0746 mL 0.1491 mL 0.3728 mL
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Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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